Correlation of Hematological Parameters on Maternal and Pediatric Leprosy ImmunityRatio: A Study in Endemic Areas in East Java, Indonesia

Authors

  • Muhammad Yulianto Listiawan
  • Flora Ramona Sigit Prakoeswa
  • Anang Endaryanto
  • Cita Rosita Sigit Prakoeswa

DOI:

https://doi.org/10.37506/ijfmt.v15i3.15882

Keywords:

Hemoglobin, Hematocrit, Maternal, Pediatric, Leprosy, Endemic

Abstract

Background: Leprosy is chronic infectious disease caused by Mycobacterium leprae. Endemic areas still
existed with stable number of new cases including new cases of pediatric leprosy and female leprosy cases.
Close contact and women’s role in household increase the risk of transmission of leprosy to their children.
Population lived in endemic areas are prone to contract leprosy due to dysregulation of immune system. This
study aims to analyze correlation of hematological parameters and immunity ration in maternal and pediatric
leprosy in endemic areas.
Methods: This is a cross-sectional study in endemic areas in Tuban Regency, East Java Province,
Indonesia. The blood sample was taken from the subjects and underwent complete hematological parameter
test (hemoglobin, red blood cells, white blood cells, platelets, hematocrit) and measurement of T cells
activityratio(Th1/Th2 ratio and Th17/Treg ratio) by ELISA. Correlation test was done between blood test
resultsand the immunity ratio of maternal and pediatric leprosy in endemic areas.
Results: 33 pairs of maternal and pediatric leprosy cases were analyzed. This study found correlation
between RBC (p value= 0.029) and HCT (p value= 0.038) with Th17/Treg ratio in children population. No
significant results observed in mothers population.
Conclusion: The result of this study shows that hematological paramaters (HB and HCT) related to the
Th17/Treg ratio and could play roles in the incidence of dysregulation of immune system in children leprosy.

Author Biographies

Muhammad Yulianto Listiawan

Associate Professor, Department of Dermatology and Venereology, Faculty of Medicine, Airlangga University /Dr. Soetomo General Academic Hospital, Surabaya, Indonesia

Flora Ramona Sigit Prakoeswa

Doctoral Candidate, Doctoral Program, Faculty of Medicine, Airlangga University, Indonesia

Anang Endaryanto

Associate Professor, Department of Pediatric, Faculty of Medicine, Airlangga University Dr. Soetomo General Academic Hospital, Surabaya, Indonesia

Cita Rosita Sigit Prakoeswa

Professor, Department of Dermatology and Venereology, Faculty of Medicine, Airlangga University / Dr. Soetomo General Academic Hospital, Surabaya, Indonesia

Published

2021-05-17

How to Cite

Listiawan, M. Y., Sigit Prakoeswa, F. R. ., Endaryanto, A. ., & Sigit Prakoeswa, C. R. . (2021). Correlation of Hematological Parameters on Maternal and Pediatric Leprosy ImmunityRatio: A Study in Endemic Areas in East Java, Indonesia. Indian Journal of Forensic Medicine & Toxicology, 15(3), 3767-3771. https://doi.org/10.37506/ijfmt.v15i3.15882

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