Cardio-renal Protective Role of Alpha Lipoic Acid Against Mesterolone in Relation to ANP, Nrf2 and TSPO genes
Keywords:Mesterolone, Lipoicacide, ANP, Nrf2, TSPO.
The protective role of Alpha Lipoicacide on cardio_renal function in rabbits subjected to Mesterolone was
studied. A total of twenty adult female rabbits was divided into fourgroups:Control,Mesterolone(0.65mg/
kg B.w),Lipoic acid(10 mg/kg B.w) and Mesterolone +Lipoic acid.All animals received treatment every
day for 60 days by oral administration during the period from 1stAugust 2018 to 1st June 2019. At the
end of the experiment, animals were anesthetized by double dose anesthesia, heart and kidney tissues for
RNA isolation were taken.This retrospective study was carried out in Department of physiology/College of
Veterinary Medicine/University of Baghdad/Iraq. The heart and kidney tissue were isolated for the expression
of atrial natriuretic peptide,nuclear factor erythroid 2 related factor 2 and Translocator protein genes.The
results showed a significant increase in the expression of the genes in Mesterolonegroup.Whereas, Lipoic
avid supplementation decreases them. These results indicate the important effect of Alpha lipoic acid on
cardiorenal function. These anabolic androgenic steroids such as Mesterolone exert an up regulation of atrial
natriuretic peptide,nuclear factor erythroid 2 related factor 2 and Translocator protein genes expression to
overcome the damage of heart and kidney tissue induced by them.
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