A Review: Quorum Sensing Phenomenon: Regulation of biofilm in Pseudomonas aurogenosa
Keywords:Cystic Fibrosis, Type IV pili (TFP), Alginate, Quorum sensing
It is been mentioned that Pseudomonas aeruginosa, a ubiquitous, gram negative, can infect patients with
Cystic fibrosis. Treatment of infections can often be difficult due to its ability to produce biofilm. It has been
revealed that biofilms are enclosing architecture that would consist of planktonic cells to survive in harsh
environments. Biofilm is usually comprised of Pel, Psl, and Alginate, and many others to make a scaffold
that bacteria can attach and start making microcolonies. The formation of the biofilm and Alginate layer is
shown to be controlled by intricate cell-to-cell communication known as quorum sensing (QS). Finally, in
this report, we have taken the basic principles of what is P.aerogenosa, and how it is related to the cystic
fibrosis disease. Also, we have illustrated the formation of biofilms and the regulation of biofilms to the
quorum sensing LasR/LasI and RhlR/RhlI systems.
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