Immune Response to Burn Injury: Hyperinflammation and Immunosuppression


  • Septin Mauludiyana
  • Aryati
  • Yoes Prijatna Dachlan
  • Iswinarno Doso Saputro
  • Muhaimin Rifa’i



Immune response, Burn Injury, Hyperinflammation, Immunosuppression


Burn is an injury to the skin or other tissue. Mostly, it caused by contacting with hot liquids, solids, and
flames. The important thing that should be consider in burn incident is the severity of burn and it based on
the depth and area of the burn injury. The severity of burns will cause differences of pathophysiological
responses. This was a literature review study. Various articles were collected from online database including
reports, journals, and published in the last 10 years. The articles were from the scholar journals. The systemic
inflammatory response in severe level of burns was not given good response to disappear of lesion burn
and initiating tissue repair. Moreover, it was given an organ failure to the patient. The body responded
to this incident by releasing antiinflammatory mediators. This response is very strong and prolonged, so
it caused immunosuppression and increase the risk of secondary infection to the patients. Burns affects
the patient’s immune system. The ratio between pro and antiinflammatory mediators are determining the
patient’s subsequent status.

Author Biographies

Septin Mauludiyana

Doctoral Student, Post Graduate Doctoral Program, Faculty of Medicine, Airlangga University, Indonesia,


Professsor, Department of Clinical Pathology, Faculty of Medicine, Airlangga University, Dr. Soetomo General Hospital, Indonesia,

Yoes Prijatna Dachlan

Professsor, Department of Parasitology, Faculty of Medicine, Airlangga University,

Iswinarno Doso Saputro

Head of Department of Plastic Reconstructive and Aesthetic Surgery, Faculty of Medicine, Airlangga
University, Dr. Soetomo General Hospital, Indonesia

Muhaimin Rifa’i

Professsor, Head of Department of Biology, Faculty of
Mathematics and Natural Science, Brawijaya University, Indonesia



How to Cite

Septin Mauludiyana, Aryati, Yoes Prijatna Dachlan, Iswinarno Doso Saputro, & Muhaimin Rifa’i. (2021). Immune Response to Burn Injury: Hyperinflammation and Immunosuppression. Indian Journal of Forensic Medicine & Toxicology, 15(3), 4095-4099.

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