The Accuracy of Indonesian New Local Skin Prick Test (SPT) Allergen Extracts as Diagnostic Tool of IgE-mediated Atopic Dermatitis

Authors

  • Sylvia Anggraeni
  • Menul Ayu Umborowati
  • Damayanti
  • Anang Endaryanto
  • Cita Rosita Sigit Prakoeswa

DOI:

https://doi.org/10.37506/ijfmt.v15i3.15965

Keywords:

atopic dermatitis, allergen extracts, skin prick test, specific IgE, accuracy.

Abstract

Background: Skin Prick Test (SPT) is good diagnostic tool of allergic disease such as Atopic Dermatitis
(AD). Imported allergen extracts are expensive and not always available in Indonesia. New local SPT
allergen extracts are potential as substitute.
Objective: To compare SPT results of new local and imported allergen extracts (house dust mite, chicken,
egg white, cow’s milk, and shrimp), and specific IgE in AD patients.
Methods: This was clinical trial of 45 non lesional AD patients. The SPT of imported allergen extracts was
performed in the first week, followed by the new local and specific IgE examination in the next one week.
Result: Sensitivity (Sn) of new local compared with imported allergen extracts in this study was between
15.38%-84.61%, the highest point was house dust mite extract. Specificity (Sp) was ranged from 81.48%-
93.75%, the highest rank was shrimp extract. Compared with IgE results, the Sn of new local and imported
house dust mite extracts was good (85.7%; 92.9%). The Sp was good for egg white and cow’s milk new local
extracts (86.4%; 84.4%).
Conclusion: New local allergen extracts should be considered as a substitute of the imported diagnostic tool.

Author Biographies

Sylvia Anggraeni

Researcher, Post Graduate Doctoral Program, Faculty of Medicine Universitas Airlangga, Indonesia

Menul Ayu Umborowati

Researcher, Department of Dermatology and Venereology, Faculty of Medicine Universitas Airlangga/ Dr.
Soetomo General Academic Hospital, Surabaya, Indonesia

Damayanti

Researcher, Department of Dermatology and Venereology, Faculty of Medicine Universitas Airlangga/ Dr.
Soetomo General Academic Hospital, Surabaya, Indonesia

Anang Endaryanto

Researcher, Department of Pediatric, Faculty of
Medicine Universitas Airlangga/ Dr. Soetomo General Academic Hospital, Surabaya, Indonesia

Cita Rosita Sigit Prakoeswa


Professor,
Department of Dermatology and Venereology, Faculty of Medicine Universitas Airlangga/ Dr. Soetomo General
Academic Hospital, Surabaya, Indonesia

Published

2021-05-17

How to Cite

Sylvia Anggraeni, Menul Ayu Umborowati, Damayanti, Anang Endaryanto, & Cita Rosita Sigit Prakoeswa. (2021). The Accuracy of Indonesian New Local Skin Prick Test (SPT) Allergen Extracts as Diagnostic Tool of IgE-mediated Atopic Dermatitis. Indian Journal of Forensic Medicine & Toxicology, 15(3), 4278-4285. https://doi.org/10.37506/ijfmt.v15i3.15965

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