The Evaluation of 3-(2-Hydroxyphenyl)-1-Phenyl–Propenone as a Targeted Drug for Wound Healingin Sprague dawleyRats
Keywords:chalcone; wound healing;Masson’s trichrome staining; Hsp70;Bax and TGF.
This study designed to evaluate the effects of 3-(2-Hydroxyphenyl)-1-phenyl–propenone (HPPP) as a
targeted drug on enhancement the process of wound healing in Sprague dawley (SD) rats. A skin excision
wound was dissected from posterior neck area of each rat. Group 1 received no treatment, while group
2 received Intrasite gel treatment. Wounds of groups 3 and 4 were dressed with HPPP 25 and 50 mg/
kg, respectively. After 10 days, histological evaluation, immunohistochemistry and biochemical analysis
were investigated.Catalase (CAT), superoxide dismutase (SOD)enzymes and malondialdehyde (MDA)
levels were determined in wound homogenates.Groups 3 and 4 showed remarkably a higher rate of wound
healing process when compared with the others. The microscopic results indicated increases in fibroblasts,
collagen fibers and angiogenesis. Moreover, chalcone groups showed respectively an increase and reduction
in antioxidant activity, and lipid peroxidation level. There were no signs of toxicity or mortality in the acute
toxicity experiment up to 1000 mg/kg.Our data provided an evidence for the first time that HPPP could
hasten significantly the wound healing process in rats.
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