PAX2 Expression in Endometrial Intraepithelial Neoplasia

Authors

  • Zahra Abbas Fadhil
  • Sazan Abdulwahab Mirza
  • Sahira Abood Ali

DOI:

https://doi.org/10.37506/ijfmt.v15i3.15983

Keywords:

Endometroid carcinoma, PAX2,Endometrial intraepithelial neoplasia

Abstract

Endometrial intraepithelial neoplasia (EIN) is a clonal growth of glands of the endometrium, regarded
as a precancerous condition because of its highcorrelation with endometrioid adenocarcinoma of the
endometrium of uterus.
Objective: To evaluate the expression of PAX2 in EIN and to correlate the expression with clinical
parameters.
Materials and Methods: - This is a retrospective study for (57)totalcasesof D&C and endometrial pipple
biopsies, (21) cases where diagnosed as hormonal imbalance, (26) cases where diagnosed as EIN and (10)
cases where diagnosed as endometrioid endometrial adenocarcinoma.
Results: -Total number of cases that showed completely loss of PAX2 expression in all this study groups
25/57 and cases that showed partial loss 10/57. In hormonal imbalance group: all the cases showed normal
expression of PAX2. In EIN: (65.4%) of cases were with complete loss of PAX2, (30.4%) with partial loss.
In endometrial endometrioid cancer group:80% of cases with complete PAX2 expression, while partial
loss or decrease PAX2 expression did occur in only (20%) ofcases.The association between study groups
and PAX2 expression:decrease and complete loss of PAX2 staining were significantly (P= 0.001) occurred
in cases of EIN and endometrial endometroid adenocarcinoma, while there was insignificant association
(P=0.635) between study groups (EIN and endometrial endometroid adenocarcinoma), and results of PAX2
expression.
Conclusion: -Loss of PAX2 immunomarkerexpressionhappens early and during of EIN using the WHO
diagnostic categories.

Author Biographies

Zahra Abbas Fadhil

Researcher, M.B.Ch.B Resident Doctor. Department of Pathology, Collage of Medicine, University of Baghdad

Sazan Abdulwahab Mirza

Supervisor Ass. Prof. M.B.Ch.B, F.I.C.M (Pathology). Department of Pathology, Collage of Medicine, University of Baghdad

Sahira Abood Ali

Supervisor M.B.Ch.B, MSc. PhD (Pathology)Department of pathology, Collage of Medicine, University of Baghdad

Published

2021-05-17

How to Cite

Fadhil, Z. A., Mirza, S. A. ., & Ali, S. A. . (2021). PAX2 Expression in Endometrial Intraepithelial Neoplasia. Indian Journal of Forensic Medicine & Toxicology, 15(3), 4410-4418. https://doi.org/10.37506/ijfmt.v15i3.15983