Physiological and Molecular Study for Some Cases of Coronary Artery Disease
Keywords:Coronary artery disease, Physiological, GSTM1, GSTT1
Coronary artery diseases (CAD) known as the disorders of the heart and the blood vessels, which claimed
17.1 million lives a year worldwide. to identify the correlation between the coronary artery disease and some
physiological and molecular parameters in men. one hundred blood samples (5 ml) collected from coronary
artery diseases patients, the Complete blood count parameters (CBC), Serum concentrations of Creatinine,
Glucose, Cholesterol, Triglycerides, HDLLDL, T3 , T4 and TSH were measured in current study. Multiplex
polymerase chain reaction used to determine the presence or absence of GSTM1 and GSTT1 genes in the
genomic DNA and CYP1A1 as an internal control. The results of current study showed significant increase
in the total WBC, Neutrophil, Lymphocyte, MCH, MCHC,PLT, MPV, PCT, creatinine, glucose, cholesterol,
Triglyceride, LDL andTSH in patients group when compared with control.The percentage of coronary artery
diseases were increase 47% when the GSTM1 gene absence in patients group compared with control,while
no significant differences were recorded when GSTT1 gene absence and the two genes absence in patient
group compared with control.The study concluded that physiological indicators may increase in patients
with Coronary artery diseases .
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