Invasion of Diabetic and Atherosclerotic Vessels Patients with Periopathogen Spirochete Treponema denticola in Iraqi Population
DOI:
https://doi.org/10.37506/ijfmt.v15i3.16219Keywords:
Periodontitis, Atherosclerosis Biofilms, Spirochete Treponema denticola, Serotype-specific primers of 16S ribosomal-RNA gene and PCR.Abstract
Both Periodontitis & Atherosclerosis of Cardiovascular system are chronic inflammatory disorders can be
performed by invasion of their connective tissues with aerobic & anaerobic infectious bacteria & formation
of polymicrobial biofilms. Microbial & metabolic plaques are considered to be the initiating factor for many
infectious & metabolic diseases, invasion of an oral & systemic organs with various opportunistic pathogens
have been reported in many populations. Several studies have been published Conventional & Real time
PCR with 16S r RNA gene to improve the existence of the DNA molecules of the most invasive periodontics
pathogens in atheromatous plaques of diabetic & cardiovascular blood vessels disease patients.
In the present study, among 100 atherosclerotic & diabetic patients suffered from various degrees of ischemic
heart disease, the DNA molecules of Treponema denticola was detected in (45/100)45% of atheromatous
plaque samples significantly in male 28 /45 (62%) more than 17/45(38%) in female patients (p = 0.07) with
no significant importance in cardiovascular & diabetic patients more than 50 years old 23/45(51%) which
was approximate to 22/45(49%) in younger than 50 years old. As well as, T. denticola DNA molecules were
significantly displayed in atheromatous plaques of type (1, 2) diabetic patients 35 /45 (78%) more than in
non-diabetic group 10/45(22%) (p= 0.07) & T. denticola DNA molecules did not displayed in the controller
group.
In conclusion: the present cross sectional study demonstrated the invasion of atheromatous plaques of
cardiovascular atherosclerotic vessels & diabetic patients with highly aggressive anaerobic periodontal
spirochetes T. denticola, these results improve the existence of additional risk factor that interfere with
the pathogenesis of periodontitis & genesis of cardiovascular atherosclerosis & may be correlated with the
atherosclerosis & diabetes mellitus diseases patients in Iraqi population.
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