The Role of Silver Nanoparticles Against Amoxicillin/ Clavulanate-Induced Liver Damage in the Female Rats
Keywords:Amoxicillin/Clavulanate acid, Silver Nanoparticles, Liver Damage
The current study was designed to evaluate the protective effect of silver nanoparticles against toxicity
induced by amoxicillin/clavulanate acid. Number of rats in the experiment are nine divided into three groups
each group has three rats. The first group is kept as control group and administrated normal saline, the second
is administered amoxicillin/clavulanate acid at dose 80 mg/kg and third group is administered amoxicillin/
clavulanate acid at dose 80 mg/kg and silver nanoparticles at dose 50 mg/kg for 30 days. The results show
significant increase (p<0.05) in the liver aminotransferase levels (AST, ALT and ALP), total protein and
albumin in addition significant increase (p<0.05) in the lipid profile total cholesterol TC, triglyceride TG,
low density lipoprotein LDL, very low density lipoprotein VLDL and significant decrease (p<0.05) in
the high density lipoprotein HDL incompare with control group. In conclusion: silver nanoparticles has
beneficial effectagainst side effects induced by amoxicillin/clavulanate acid in rats.
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