The Correlation Study between Some Biochemical Parameters of 256 Covid-19 Cases Considering Diabetes

Abstract

Background: Diabetic Mellitus is an independent risk factor in patients with coronavirus disease 2019
(COVID-19), but data on the association of diabetes, acute kidney injury, and COVID-19 severityare limited
to Middle East populations.
Materials and Methods: This cohort study aimed to investigate these associations in 256 patients
sequentially admitted between June 2020 and November 2020, at Emirati Hospital/Erbil. The investigation
included some main biochemical parameters including liver and kidney function tests. Data analysis was
processed by SPSS and the Pearson correlation pathway using log-converted data.
Results: Diabetic patients showed the highest correlations between measured parameters, of which glucose
level showed a positive correlation coefficient (0.13**) with C-reactive protein and other biochemical
parameters. Based on the glycemic status, COVID-19 patients were found in 3 groups, euglycemia group
with an abundance of 148 (57.81%),hyperglycemiapatients were 67 (26.17%), and 41 of them were diabetics
(16.01 %).
The Diabetic group showed a significantly (0.0002) increased level of C-reactive Protein and Glucose in
comparison with hyperglycemia [CRP 15.38 mg/dl vs 10.09mg/dl, glucose 429.75 mg/dl vs 160.62mg/
dl] with a Significantly (0.00374) higher mortality rate (29.26%) than that (10.44%), and (6.75%) of
hyperglycemia, and euglycemia, respectively.
Conclusion: Male COVID-19 cases showed higher correlations between the estimated parameters than
female cases. Diabetes was significantly associated with elevation of almost all kidney and liver function
parameters. Finally, diabetes followed by COVID-19 disease was related to severe complications and higher
mortality rates than nondiabetic COVID-19 cases.