Induced Hyperlipidemia in Adult Male Rats and Treated by using Rosmarinus officinalis Aqueous Extract

Abstract

The current work was goaled to revealed anti-hyperlipidemia activity of R. officinalis extract. This work
utilized 20 male rats that divided to negative group; positive group was given drinking water containing
0.5% H2O2 and (1%) cholesterol for 60 days. Third group: hyperlipidemia rats were treated with (50mg/
kg/daily) extract. Fourth group: hyperlipidemia rats were treated with (100mg/kg/daily) extract. The
outcomes revealed significant (P < 0.05) rise in cholesterol and triglyceride and reduce the HDL in positive
group compare with negative group. Malonedialdehyied (MDA) was increased with reduce in glutathione
(GSH) compare with negative group. Otherwise, diameters of aorta artery show significant (P < 0.05) rise
compare with negative group. R. officinalis aqueous extract when used in treatment, the outcomes exhibited
improvement in lipid profile, MDA, GSH and diameters of aorta artery compare with negative group. It was
concluded that R. officinalis extract possess anti-hyperlipidemia activity.