Correlation between Interleukin(IL-6) and Procalcitonin (PCT) Level among Diarrheal Children

Abstract

This study was conducted his study was conducted in Baghdad for the period from December 1, 2019
to June 3, 2020 for determination of the level of elevation of interleukin-6 and procalcitonin in children
with acute diarrhea, I was included 50 children suffering from diarrhea and 50 children without any other
disease, where the ages of children in both groups ranged from one month to five years. The study included
collecting information from children in both groups, including gender, age, living situation, number of
family members, standard of living and social as well as the number of family members, number of rooms
in the house. Amount of 5 ml of blood samples were collected from all the children included in this study,
where the blood samples were separated by the centrifuge device and the serum samples were separated
from them and kept in the refrigerator until the tests for detecting the level of Interleukin 6 and procalcitonin
using ELISA technique. In this study, 76 % of diarrheal children were suffered from abdominal pain, 68%
with dehydration, 58% of fever, 46% had vomiting.The presented study found that, 78% of families with
diarrheal children were lived in crowed houses, 73% didn’t wash vegetables before eat, 69% haven’t wah
hands, 66 used tap water for drinking.In this study, IL-16 was observed in elevated mean in diarrheal children
(19.66±2.19 ng/ml), when it compared with the control healthy children (4.27±1.46 ng/ml) (P<0.001).In this
study, procalcitonin was also observed in elevated mean in diarrheal children (42.17±9.28 ng/ml), when
it compared with the control healthy children (28.19±8.27 ng/ml) (P<0.001).The study showed that the
maximum means of PCT and IL-6 in diarrheal children were observed in those with fever, followed by
abdominal pain. The study revealed a significant positive correlation between IL-6 and PCT level among
diarrheal children.Conclusions:The study showed a significant relation of PCT and IL-6 with diarrhea..