A comparative Study of Efficacy of Esmolol and Fentanyl For Blood Pressure and Heart Rate Attenuation During Laryngoscopy and Endotracheal Intubation

Abstract

Background: Blood pressure and heart rate elevation during laryngoscopy and tracheal intubation may
cause serious medical problems ex.: patients with cardiovascular disease as well as patients with increased
intracranial pressure. Aim of study: Comparism between Fentanyl and Esmolol in attenuating blood pressure
and heart rate during laryngoscope and tracheal intubation. Patients and Method:60 adult patients of both
sex, ages between (20-33) , labeled as ASA I and ASA II will undergo elective surgery, divided into two
groups, each group contain 30 patients: Esmolol Group (E) takes 0.5 mg/kg esmolol IV. And Fentanyl Group
(F) takes 1 mic/kg fentanyl IV.Blood pressure and heart rate was recorded before drugs administration as
baseline reading and another reading was taken after drug administration as well as after tracheal intubation.
Result: blood pressure and heart rate readings of both groups, when compared to baseline reading shows
that Regarding heart rate, there are significance differences between the two groups, in that, esmolol
reduce heart rate in all stages when compared to fentanyl. Regarding systolic blood pressure, both drugs
reduce systolic blood pressure and there are significances in all stages, favored esmolol except in T3 due to
rise in sbp when using fentanyl. Regarding diastolic blood pressure, both drugs also reduce diastolic blood
pressure but there are no significances in these reading except in T3 due to esmolol reduce dpb much more
than fentanyl does. Conclusions: esmolol in a dose of 0.5mg/kg is more effective than fentanyl in a dose of
1mic/kg in attenuation of hemodynamic response after endotracheal intubation.