Investigation the Role of IL-17 rs2275913 Gene Polymorphism with the Risk of Osteoporosis in a Sample of Iraqi Pre and Postmenopausal Women

Authors

  • Asmaa Mahmoud Salman
  • Da'ad A. Hussain

DOI:

https://doi.org/10.37506/ijfmt.v15i4.16804

Keywords:

Low Bone Mineral Density, IL-17, Single-nucleotide polymorphism Susceptibility, Baghdad Teaching Hospital.

Abstract

Objective: This study aimed to investigate the relationship between the genetic polymorphism and alleles
frequencies of IL-17 rs2275913 G/A with the risk of low bone mineral density (osteoporosis and osteopenia).
Furthermore studying the relation between some immunological and biochemical parameters with this
disease in a sample of Iraqi pre and postmenopausal women. Methodology: In this study, we investigated
about the IL-17 rs2275913 G/A polymorphisms and the risk of low bone mineral density (BMD) among
30 patients with osteopenia, 30 patients with osteoporosis and 30 healthy controls. Serum IL-17 level and
its correlation with the IL-17 rs2275913 G/A genotypes were analyzed. The study was carried out from
November 2020- January 2021 in Baghdad Teaching Hospital/ Bone density examination unit/ in Baghdad-
Iraq. Conclusion: It is concluded that the IL-17 rs2275913 G/A genotype was not associated with increased
risk for development of low (BMD) in Iraqi pre and postmenopausal women. Recommendation: Based on
study conclusion, during menopause, it is important for women to have a DEXA scan to detect low BMD
and receive appropriate care to prevent degradation of the micro-architecture of bone tissue, which increases
the risk of bone fractures.

Author Biographies

  • Asmaa Mahmoud Salman

    Scholar Researcher, Institute of Genetic Engineering and Biotechnology, University of Baghdad, Iraq

  • Scholar Researcher, Institute of Genetic Engineering and Biotechnology, University of Baghdad, Iraq

  • Da'ad A. Hussain

    Scholar Researcher, Institute of Genetic Engineering and Biotechnology, University of Baghdad, Iraq

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Published

2021-08-16

How to Cite

Investigation the Role of IL-17 rs2275913 Gene Polymorphism with the Risk of Osteoporosis in a Sample of Iraqi Pre and Postmenopausal Women. (2021). Indian Journal of Forensic Medicine & Toxicology, 15(4), 810-815. https://doi.org/10.37506/ijfmt.v15i4.16804