Investigation the Role of IL-17 rs2275913 Gene Polymorphism with the Risk of Osteoporosis in a Sample of Iraqi Pre and Postmenopausal Women

Abstract

Objective: This study aimed to investigate the relationship between the genetic polymorphism and alleles
frequencies of IL-17 rs2275913 G/A with the risk of low bone mineral density (osteoporosis and osteopenia).
Furthermore studying the relation between some immunological and biochemical parameters with this
disease in a sample of Iraqi pre and postmenopausal women. Methodology: In this study, we investigated
about the IL-17 rs2275913 G/A polymorphisms and the risk of low bone mineral density (BMD) among
30 patients with osteopenia, 30 patients with osteoporosis and 30 healthy controls. Serum IL-17 level and
its correlation with the IL-17 rs2275913 G/A genotypes were analyzed. The study was carried out from
November 2020- January 2021 in Baghdad Teaching Hospital/ Bone density examination unit/ in Baghdad-
Iraq. Conclusion: It is concluded that the IL-17 rs2275913 G/A genotype was not associated with increased
risk for development of low (BMD) in Iraqi pre and postmenopausal women. Recommendation: Based on
study conclusion, during menopause, it is important for women to have a DEXA scan to detect low BMD
and receive appropriate care to prevent degradation of the micro-architecture of bone tissue, which increases
the risk of bone fractures.