Peutz Jeghers Syndrome in 47 Years Old Woman (Histopathological Review) : Case Report

Authors

  • Danu Yuliarto
  • Prasetyadi Mawardi
  • Ambar Mudigdo

DOI:

https://doi.org/10.37506/ijfmt.v15i4.16835

Keywords:

Peutz-jeghers Syndrome, Histopathology, Melanocytes

Abstract

Background: Peutz-Jeghers syndrome (PJS) is an autosomal dominant inherited disorder, characterized
by intestinal hamartoma polyps in association with distinct patterns of skin and mucosal macular melanin
deposition. Patients with PJS have a 15-fold increased risk of developing bowel cancer compared to the
general population.
Case: A 47-year-old woman complained of black patches appearing on the lower and upper lips. Several
months ago, the patient said that black patches appeared on the gums and inner cheeks. Gastrointestinal
complaints such as nausea or vomiting were previously denied. Dermatological examination in the oris
et ginggiva et buccalis region showed multiple well-defined hyperpigmented macules. Histopathological
examination found an increase of melanocytes in the stratum basale with rows of melanocytes. Patient
had an endoscopy in the gastrointestinal tract and histopathological examination of the colonic mucosa, no
abnormalities were found and no signs of malignancy were found on histopathological examination.
Conclusion: Result of histopathological examination showed an increase in the number of melanocytes
in the stratum basale with lined melanocytes. Based on histopathological examination in this patient more
leads to the diagnosis of PJS

Author Biographies

Danu Yuliarto

Recidency Program, Department of Dermatology and Venereology, Faculty of Medicine, Sebelas Maret University/ Dr. Moewardi General Hospital, Surakarta, Indonesia

Prasetyadi Mawardi

Associate Professor in Department of Dermatology and Venereology, Faculty of Medicine,
Sebelas Maret University/ Dr. Moewardi General Hospital, Surakarta, Indonesia

Ambar Mudigdo

Professor in Department of Anatomical Pathology, Faculty of Medicine, Sebelas Maret University/ Dr. Moewardi General Hospital, Surakarta,Indonesia

Published

2021-08-16

How to Cite

Danu Yuliarto, Prasetyadi Mawardi, & Ambar Mudigdo. (2021). Peutz Jeghers Syndrome in 47 Years Old Woman (Histopathological Review) : Case Report. Indian Journal of Forensic Medicine & Toxicology, 15(4), 983-988. https://doi.org/10.37506/ijfmt.v15i4.16835