Immunological and Biological Manifestation of Rheumatoid Arthritis Patient in Iraq

Abstract

Rheumatoid arthritis is one of the highly incidence autoimmune disease. In present study the immunological
and clinical biochemical test was checked in patients with RA in Iraq. Here 70 serum specimens were
obtained from patients suffer from RA and 30 serum specimens from healthy control cohorts. Antinuclear
antibodies (ANA) level, C-reactive protein level, erythrocyte sedimentation rate (ESR), activity of alanine
aminotransferase (ALT), activity of aspartate aminotransferase (AST), concentration of blood urea and
serum creatininand diseases activity score (DAS)-28 were evaluated in sera of patients and healthy control
cohorts. The results showed that significant elevation in level of ANA, ESR, CRP and DAS-28 in patients
group as compared to healthy control group (P<0.05). No significant difference between patients group and
healthy control group in terms of activity of ALT, AST, concentration of blood urea and serum creatinine.
The person test (r) was done to evaluate the correlation between ESR, ANA, CRP, ALT, AST, blood urea and
serum creatinine. The results showed significant relation between levels of ESR, CRP and ANA and activity
of disease in terms of DAS-28. The results showed no significant relation between level of CRP, ALT, AST,
blood urea and serum creatinine in patient’s sera and DAS-28. It can be concluded from present study that
the some laboratory parameters related with activity of RA such as ESR, ANA, CRP and other parameters
do not related with activity of RA such asALT, AST, blood urea and serum creatinine.