Synthesis and Characterization of New Oxo-Aztedine ,Imidazoldine and Thiazolidine Rings on Creatinine and Evaluation of their Biological Activity

Authors

  • RaadM.Muhiebes
  • Entesar O. AL-Tamimi

DOI:

https://doi.org/10.37506/ijfmt.v15i4.16904

Abstract

This work included preparation of new imine from the reaction of creatinine with aldehydes (4-nitro
benzaldehyde, 4- amino benzaldehyde, cinnamaldehyde) and ketone ( acetophenone ) in ethanol and the
presence of few drops glacial CH3COOH to obtain Schiff bases (1a,1b,1c,1d) Schiff bases were treated
with monochloroacetyl chloride to produced (2a,2b,2c,2d), with glycine to synthesis (3a,3b,3c,3d) and
with 2-mercaptoacetic acid to prepare (4a,4b,4c,4d). The Prepared compounds had beenmeasured by (FTIR,
and1HNMR ) spectroscopic techniques. Some of the derivatives were studied activity against antibacterial,
antifungal and antioxidant.

Author Biographies

  • RaadM.Muhiebes

    Research Scholar, Chemistry Department, Faculty of Science, University of Baghdad, Iraq

  • Entesar O. AL-Tamimi

    Professor, Chemistry,Department, Faculty of Science, University of Baghdad, Iraq

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Published

2021-08-16

How to Cite

Synthesis and Characterization of New Oxo-Aztedine ,Imidazoldine and Thiazolidine Rings on Creatinine and Evaluation of their Biological Activity. (2021). Indian Journal of Forensic Medicine & Toxicology, 15(4), 1405-1411. https://doi.org/10.37506/ijfmt.v15i4.16904