Correlation between Superoxide Dismutase 1 and 2 Polymorphisms in Asthma Patients

Abstract

This study was designed to investigate the effectof polymorphisms of Superoxide desmutase1 and 2genes
and how they contribute to the risk of developing asthma.A total 120 were involved in the present study and
divided into four groups and each group included 30 samples. First group was consisted 30 asthma male
patients with waterpipe smoking and second group was also 30 asthma male patients with no smoking,
third group was control (no disease) with waterpipe smoking and the fourth group was control group
(no disease and without waterpipe smoking).Blood samples were collected from Muthanna hospital and
private laboratories from the periodmid-August to the mid-November 2020. To study the polymorphism
phenomenon of SOD1 and SOD2 genes were assessed using RFLP- polymerase chain reaction (RFLPPCR)
technique. This study confirmed that the phenomenon of polymorphism of the SOD1 genewas not
associated with the group of patients infected with asthma comparedto control group. This study conducted
that the phenomenon of polymorphism of the SOD2 geneis not associated with the group of patients infected
with asthmacomparedto control group in presence and absence of waterpipe smoking.