Disorders of Kidney Function in Chronic Heart Failure

Authors

  • Kamilova Umida
  • Abdullaeva Charos
  • Atakhodjaeva Gulchehra
  • Beknazarova Saida
  • Masharipova Dilyafruz
  • Ikramova Feruza

DOI:

https://doi.org/10.37506/ijfmt.v15i4.16928

Keywords:

chronic heart failure, renal function, cardiorenal syndrome

Abstract

The formation of cardiorenal syndrome (CRS) in patients with chronic heart failure (CHF) is a natural
manifestation of a functionally interrelated process at the organ level. Moreover, impaired renal function is a
common and independent factor in the progression of the disease, a high incidence of cardiovascular events
and death in a population of patients with asymptomatic and / or clinically manifested CHF, which is due
to the pathogenetic features of the formation of cattle in patients with CHF of ischemic genesis. The article
provides an overview of studies on the pathogenesis of kidney damage in CHF, the role of various markers
in the early diagnosis of cattle. A decrease in glomerular filtration rate (GFR) and an increase in urinary
albumin excretion are currently considered as “renal” markers of a poor prognosis within the cardiorenal
continuum. In this regard, for stratification of patients by stages of chronic kidney disease (CKD) and,
consequently, for assessing the risks of increased overall and cardiovascular mortality in patients with CHF,
the accuracy of calculating GFR, as the main indicator reflecting the severity of formed kidney damage, is of
great importance. Microalbuminuria is one of the early signs of CKD, the main cause of which is glomerular
capillary endothelial dysfunction that occurs in most patients with CHF. The presence and persistence of
subclinical renal dysfunction during treatment, even with the achievement of risk factors (RF) control and
regression of organ lesions, can adversely affect the patient’s prognosis. Assessment of the functional state
of the kidneys is important for early diagnosis, selection of effective preventive measures and treatment. The
therapeutic strategy in patients with CHF in combination with CKD should be based on the nephroprotective
effects of drugs.

Author Biographies

Kamilova Umida

Doctor of Science, Professor,  Department of Cardiology, SI “Republican Specialized Scientific and Practical Medical Center of Therapy and Medical Rehabilitation”, Osiyostreet 4, Uzbekistan Tashkent, Uzbekistan

Abdullaeva Charos

Doctor of Science, SI “Republican Specialized Scientific and Practical Medical Center of
Therapy and Medical Rehabilitation”, Osiyostreet 4, Uzbekistan Tashkent, Uzbekistan

Atakhodjaeva Gulchehra

Doctor of Science, Department of Cardiology, SI “Republican Specialized Scientific and Practical Medical Center of Therapy and Medical Rehabilitation”, Osiyostreet 4, Uzbekistan Tashkent, Uzbekistan

Beknazarova Saida

Doctor of Science,  SI “Republican Specialized Scientific and Practical Medical Center of
Therapy and Medical Rehabilitation”, Osiyostreet 4, Uzbekistan Tashkent, Uzbekistan

Masharipova Dilyafruz

Researcher,Department of Cardiology, SI “Republican Specialized Scientific and Practical Medical Center of
Therapy and Medical Rehabilitation”, Osiyostreet 4, Uzbekistan Tashkent, Uzbekistan

Ikramova Feruza

Researcher, Department of Cardiology, SI “Republican Specialized Scientific and Practical Medical Center of
Therapy and Medical Rehabilitation”, Osiyostreet 4, Uzbekistan Tashkent, Uzbekistan

Published

2021-08-16

How to Cite

Kamilova Umida, Abdullaeva Charos, Atakhodjaeva Gulchehra, Beknazarova Saida, Masharipova Dilyafruz, & Ikramova Feruza. (2021). Disorders of Kidney Function in Chronic Heart Failure. Indian Journal of Forensic Medicine & Toxicology, 15(4), 1547-1552. https://doi.org/10.37506/ijfmt.v15i4.16928

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