Disorders of Kidney Function in Chronic Heart Failure
Keywords:chronic heart failure, renal function, cardiorenal syndrome
The formation of cardiorenal syndrome (CRS) in patients with chronic heart failure (CHF) is a natural
manifestation of a functionally interrelated process at the organ level. Moreover, impaired renal function is a
common and independent factor in the progression of the disease, a high incidence of cardiovascular events
and death in a population of patients with asymptomatic and / or clinically manifested CHF, which is due
to the pathogenetic features of the formation of cattle in patients with CHF of ischemic genesis. The article
provides an overview of studies on the pathogenesis of kidney damage in CHF, the role of various markers
in the early diagnosis of cattle. A decrease in glomerular filtration rate (GFR) and an increase in urinary
albumin excretion are currently considered as “renal” markers of a poor prognosis within the cardiorenal
continuum. In this regard, for stratification of patients by stages of chronic kidney disease (CKD) and,
consequently, for assessing the risks of increased overall and cardiovascular mortality in patients with CHF,
the accuracy of calculating GFR, as the main indicator reflecting the severity of formed kidney damage, is of
great importance. Microalbuminuria is one of the early signs of CKD, the main cause of which is glomerular
capillary endothelial dysfunction that occurs in most patients with CHF. The presence and persistence of
subclinical renal dysfunction during treatment, even with the achievement of risk factors (RF) control and
regression of organ lesions, can adversely affect the patient’s prognosis. Assessment of the functional state
of the kidneys is important for early diagnosis, selection of effective preventive measures and treatment. The
therapeutic strategy in patients with CHF in combination with CKD should be based on the nephroprotective
effects of drugs.
How to Cite
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Re use and mixing of content policy- We follow Creative Commons Licence Policy. We follow CC BY. Please refer below for all details
This license lets others distribute, remix, adapt, and build upon our work, even commercially, as long as they credit us for the original creation.
- The journal allows readers to read, download, copy, distribute, print, search, or link to the full texts of its articles and allow readers to use them for any other lawful purpose.
- The journal allows the author(s) to hold the copyright without restrictions.
- The journal allows the author(s) to retain publishing rights without restrictions