Role of Serum Levels of Thymidine Kinase 1 in Diagnosis and Differentiating of Prostatic Tumor

Authors

  • Lara Balasim Al-Dahy
  • Basil O. Mohammed
  • Saad Dakhil F. Daraji
  • Mazin M. Farhan

DOI:

https://doi.org/10.37506/ijfmt.v15i4.16939

Keywords:

Serum, Thymidine Kinase 1, prostatic tumor

Abstract

Background: Both benign prostatic (BPH) and prostate (Pca) hyperplasia include prostate enlargement. The
distinction between benign prostatic hyperplasia and prostate cancer is a major challenge, since the prostatic
specific antigen (PSA) cannot be considered a reliable predictor of prostate cancer. Aims: Efficiency of
serum thymidine kinase 1 and PSA-related biomarkers in prostate tumor, BPH and PCa diagnosis and
differentiation, especially when serum PSA is in the gray (4-10 ng/ml) region and in the pronostic of these
patients after surgical therapy. Subjects and Methods: A case control and cross-sectional review. There
were 110 elderly patients (45-81 years) and 45 controle. Serum experiments involved the use of ELISA
technologies to measure tPSA, fPSA, and TK1. Result: In comparison to both of the BPH and controls, the
mean (±S D) of serum tPSA and fPSA in Pca were significantly improved (all p =0,001) while the mean
value of f PCa in comparison with BPH and control was dramatically decreased (p = 0,001) for fPSA/tPSA.
There was no difference between BPH and controls in these parameters. In both of the Pca and Controls
(P<0.001) the mean TC1 was slightly higher (P<0.001). This serum TK1 has the most receptive and specific
diagnostic and differentiating potency in the gray zone of tPSA (4-10 ng/ml), which has tPSA in the gray
zone with AUC=1 in the 924 pg/ml cut-off zone.
Conclusion: Serum level of TK1 was superior of tPSA in diagnosis of prostate tumor and differentiating
between BPH and PCa.

Author Biographies

  • Lara Balasim Al-Dahy

    Scholar Researcher, Msc, Clinical Biochemistry, Nahrain University College of Medicine, Iraq

  • Basil O. Mohammed

    Scholar researcher, PH.D Clinical Chemistry, Department of biochemistry, College of Medicine, University of Baghdad,Iraq

  • Saad Dakhil F. Daraji

    Scholar Researcher, Prof.Dr (Consultant) Urologist, Department of Urology, College of Medicine,
    University of Baghdad, Iraq

  • Mazin M. Farhan

    Scholar Researcher, Consultant Urologist, Center of Urology, Al-Yarmouk hospital, Iraq

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Published

2021-08-16

How to Cite

Role of Serum Levels of Thymidine Kinase 1 in Diagnosis and Differentiating of Prostatic Tumor. (2021). Indian Journal of Forensic Medicine & Toxicology, 15(4), 1623-1628. https://doi.org/10.37506/ijfmt.v15i4.16939