Role of Serum Levels of Thymidine Kinase 1 in Diagnosis and Differentiating of Prostatic Tumor

Authors

  • Lara Balasim Al-Dahy
  • Basil O. Mohammed
  • Saad Dakhil F. Daraji
  • Mazin M. Farhan

DOI:

https://doi.org/10.37506/ijfmt.v15i4.16939

Keywords:

Serum, Thymidine Kinase 1, prostatic tumor

Abstract

Background: Both benign prostatic (BPH) and prostate (Pca) hyperplasia include prostate enlargement. The
distinction between benign prostatic hyperplasia and prostate cancer is a major challenge, since the prostatic
specific antigen (PSA) cannot be considered a reliable predictor of prostate cancer. Aims: Efficiency of
serum thymidine kinase 1 and PSA-related biomarkers in prostate tumor, BPH and PCa diagnosis and
differentiation, especially when serum PSA is in the gray (4-10 ng/ml) region and in the pronostic of these
patients after surgical therapy. Subjects and Methods: A case control and cross-sectional review. There
were 110 elderly patients (45-81 years) and 45 controle. Serum experiments involved the use of ELISA
technologies to measure tPSA, fPSA, and TK1. Result: In comparison to both of the BPH and controls, the
mean (±S D) of serum tPSA and fPSA in Pca were significantly improved (all p =0,001) while the mean
value of f PCa in comparison with BPH and control was dramatically decreased (p = 0,001) for fPSA/tPSA.
There was no difference between BPH and controls in these parameters. In both of the Pca and Controls
(P<0.001) the mean TC1 was slightly higher (P<0.001). This serum TK1 has the most receptive and specific
diagnostic and differentiating potency in the gray zone of tPSA (4-10 ng/ml), which has tPSA in the gray
zone with AUC=1 in the 924 pg/ml cut-off zone.
Conclusion: Serum level of TK1 was superior of tPSA in diagnosis of prostate tumor and differentiating
between BPH and PCa.

Author Biographies

Lara Balasim Al-Dahy

Scholar Researcher, Msc, Clinical Biochemistry, Nahrain University College of Medicine, Iraq

Basil O. Mohammed

Scholar researcher, PH.D Clinical Chemistry, Department of biochemistry, College of Medicine, University of Baghdad,Iraq

Saad Dakhil F. Daraji

Scholar Researcher, Prof.Dr (Consultant) Urologist, Department of Urology, College of Medicine,
University of Baghdad, Iraq

Mazin M. Farhan

Scholar Researcher, Consultant Urologist, Center of Urology, Al-Yarmouk hospital, Iraq

Published

2021-08-16

How to Cite

Lara Balasim Al-Dahy, Basil O. Mohammed, Saad Dakhil F. Daraji, & Mazin M. Farhan. (2021). Role of Serum Levels of Thymidine Kinase 1 in Diagnosis and Differentiating of Prostatic Tumor. Indian Journal of Forensic Medicine & Toxicology, 15(4), 1623-1628. https://doi.org/10.37506/ijfmt.v15i4.16939