Assessment of Pesticide Biohazards in Neurodegenerative Diseases; Data Analysis Statistical Study

Authors

  • Marwan M. Merkhan
  • Zeina A. Althanoon
  • Ahmed A Mohammed
  • Ibrahim M. Faisal

DOI:

https://doi.org/10.37506/ijfmt.v15i4.16961

Keywords:

agriculture, pesticide, neurodegenerative, Alzheimer, Parkinson, epidemiology.

Abstract

Background: The initiation of late onset neurodegenerative diseases remains unknown. New researches
suggested that prolonged exposure to pesticides might lead to the initiation of neurodegenerative diseases,
but the results were subject to controversy. Aims: The present study aimed to demonstrate an update datamining
to compare published data for studies comparing role of pesticide in induction of neurodegenerative
diseases (Parkinson’s diseases, Alzheimer’s diseases, and Amyotrophic lateral sclerosis) Results: A clear
association has been noticed across different studies regarding correlation between pesticide exposure and
Parkinson’s disease or Amyotrophic Lateral Sclerosis (Odd Ratio >1), nevertheless, the association was
weaker between exposure to pesticide and the development of Alzheimer’s disease (Odd Ratio close to 1)
Conclusions: There is good quality evidence that the impact of pesticide in initiation of neurodegenerative
disease is statistically approved. However, there is inconclusive evidence from randomised controlled
trials to show significant induction of neurodegeneration. More research is needed particularly long-term
controlled studies on laboratory animals.

Author Biographies

Marwan M. Merkhan

Researcher, Department of Pharmacology and Toxicology, College of Pharmacy, University of Mosul, Mosul,
Iraq

Researcher, Department ofPharmaceutics,College of Pharmacy, Ninevah University, Mosul, Iraq

Zeina A. Althanoon

Researcher, Department of Pharmacology and Toxicology, College of Pharmacy, University of Mosul, Mosul,
Iraq

Ahmed A Mohammed

Researcher, Alkhansaa Teaching hospital, Ninevah Health Directorate, Mosul, Iraq

Ibrahim M. Faisal

Researcher, Department of Pharmacology, College of Medicine, University of Mosul, Mosul, Iraq

Published

2021-08-16

How to Cite

Marwan M. Merkhan, Zeina A. Althanoon, Ahmed A Mohammed, & Ibrahim M. Faisal. (2021). Assessment of Pesticide Biohazards in Neurodegenerative Diseases; Data Analysis Statistical Study. Indian Journal of Forensic Medicine & Toxicology, 15(4), 1783-1791. https://doi.org/10.37506/ijfmt.v15i4.16961