Assessment of Pesticide Biohazards in Neurodegenerative Diseases; Data Analysis Statistical Study
Keywords:agriculture, pesticide, neurodegenerative, Alzheimer, Parkinson, epidemiology.
Background: The initiation of late onset neurodegenerative diseases remains unknown. New researches
suggested that prolonged exposure to pesticides might lead to the initiation of neurodegenerative diseases,
but the results were subject to controversy. Aims: The present study aimed to demonstrate an update datamining
to compare published data for studies comparing role of pesticide in induction of neurodegenerative
diseases (Parkinson’s diseases, Alzheimer’s diseases, and Amyotrophic lateral sclerosis) Results: A clear
association has been noticed across different studies regarding correlation between pesticide exposure and
Parkinson’s disease or Amyotrophic Lateral Sclerosis (Odd Ratio >1), nevertheless, the association was
weaker between exposure to pesticide and the development of Alzheimer’s disease (Odd Ratio close to 1)
Conclusions: There is good quality evidence that the impact of pesticide in initiation of neurodegenerative
disease is statistically approved. However, there is inconclusive evidence from randomised controlled
trials to show significant induction of neurodegeneration. More research is needed particularly long-term
controlled studies on laboratory animals.
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