Relation between Level of Some Immunological Markers and Liver Functions with Respiratory Bacterial Infection in Sheep

Abstract

Sheep pneumonia remains an important cause of morbidity and mortality worldwide. The aim of the study
report to determine Interleukine-6,IL-10,and liver function test , and kidney function test of sheep suffering
from respiratory disease. Blood samples were collected from the diseased and healthy sheep during field
study, for biochemical analysis. The results of 50 diseased animals were compared with results of 50 healthy
animals.Data of selected biochemical parameters implicated a significant increase in Interleukin-6, alanine
aminotransferase and aspartate aminotransferase, and Gamma glutamyltransferase in the diseased group
compared to the healthy sheep’s. On the other hand, a significant decrease was seen in the levels of IL-
10, lactate dehydrogenase and total protein in the diseased group compared to the control. The results of
this study could conclude that respiratory infections in sheep were associated with significant biochemical
and immunological alterations which upon understanding can provide us with rapid diagnostic tools for
pneumonia process in sheep and thus lead to better management and proper treatment.Future research is
warranted to determine the response of individual animals to this disease and to describe the metabolic
changes which occur during the course of respiratory diseases.