Antimicrobial Peptide Cathelicidin and Vitamin D Receptor Gene Polymorphism in Oral Health

Authors

  • Nireeksha
  • Mithra N Hegde
  • Suchetha Kumari N

DOI:

https://doi.org/10.37506/ijfmt.v15i4.16997

Keywords:

Saliva, Anti-Microbial Peptide, Vitamin D, Dental Caries, Periodontitis.

Abstract

Background: Anti-microbial peptides and vitamin D levels in saliva, GCF play an important role in oral
health and its maintenance. The peptide levels are regulated by the Vitamin D cathecidilin pathway and their
association and influence on oral health is of outmost importance. The aim of the present review article is to
establish The aim is to establish a relationship and possibly the role of Cathelicidins and Vitamin D receptor
gene polymorphism in relation to oral health
Methodology: The preferred reporting items for systematic review ad meta analysis (PRISMA) were used
for reporting this systematic review. The study protocol has been approved by all co-authors .The study has
been registered at the National institute for health research (NHR) under the Prospero ID: CRD42020200946.
Results: A total of 102 articles were retrieved through electronic database search .After evaluating the title,
abstract and full text of these articles only 7 were selected for the present systematic review. However 3
articles were excluded because they were classified as high risk of bias according to PRISMA guidelines.
Out of 7 studies selected,4 were classified as low risk bias and 3 were classified as moderate riskbias.
Conclusion: The current evidence suggests anti-microbial peptide LL-37 and vitamin D receptor gene
polymorphism plays an important role in caries prevalence and periodontal health
Highlight: Understanding the role of antimicrobial peptides in saliva helps in enhancing focus on the effect
of these components on oral health and its maintenance.

Author Biographies

Nireeksha

Lecturer, Department of Conservative Dentistry and Endodontics,
A.B.Shetty Memorial Institute of Dental Sciences, Nitte University(deemed to be) Deralakatte, Mangalore

Mithra N Hegde

Vice Principal, Head of the Department, Department of Conservative Dentistry and Endodontics,
A.B.Shetty Memorial Institute of Dental Sciences, Nitte University(deemed to be) Deralakatte, Mangalore

Suchetha Kumari N

Professor, Department of Biochemistry, K.S.Hegde Medical Academy, Nitte University(deemed to be) Deralakatte,Mangalore

Published

2021-08-16

How to Cite

Nireeksha, Mithra N Hegde, & Suchetha Kumari N. (2021). Antimicrobial Peptide Cathelicidin and Vitamin D Receptor Gene Polymorphism in Oral Health. Indian Journal of Forensic Medicine & Toxicology, 15(4), 2011-2017. https://doi.org/10.37506/ijfmt.v15i4.16997