Qari (Male Voice) Increases Higher Expression of Synapsin 1 than Qariah (Female Voice) in the Cerebrum Newborn Rattus Norvegicus

Abstract

Introduction: Pregnancy is the golden period to prepare children for the future. Stimulation is needed
during pregnancy, one of which is brain stimulation. This can be done with Al Qur’an Murrotal Surah
Ar-Rahman stimulation. This study aims to analyze expression of synapsin 1 in the cerebrum of newborn
Rattus norvegicus when given murrotal Surah Ar-Rahman stimulation by qari, qariah, and not given any
stimulation during pregnancy.
Methods: Experimental with post-test only control group design. Sampling in this study was considered
homogeneous because it met the inclusion criteria. The samples obtained were distributed randomly to each
experimental group and randomized into 3 groups, including control group, group stimulated by qari, and
group stimulated by qariah. The treatment was given on the 6th day of pregnancy for 1 hour in a soundproof
room with an intensity of 65 dB.
Results: The highest mean expression of synapsin 1 in the cerebrum is qari group (6.96 ± 2.59), then qariah
group (5.84 ± 2.90), and the lowest is control group (5.74 ± 2.32). There is no significant difference in
expression of synapsin 1 in the cerebrum between control and qari groups (p = 0.306), control and qariah
groups (p = 0.932), qari and qariah groups (p = 0.347).
Conclusion: The highest expression of Synapsin 1 in the cerebrum of newborn Rattus norvegicus is the
group stimulated by qari.