Effect of Thunbergia Laurifolia Lindl. on Oxidative Stress and Blood Cholinesterase in farm Workers Exposed to Pesticides in the Mae Chai District of Phayao Province

Authors

  • Orapin Insuan
  • Padchanee Sangthong
  • Pennipat Nabheerong
  • Surachat Buddhisa
  • Peerawan Kengsangunsit
  • Suntorn Prompao
  • Benchaluk Thongchuai

DOI:

https://doi.org/10.37506/ijfmt.v15i4.17014

Keywords:

Rang Chuet, butyrylcholinesterase, malondialdehyde

Abstract

Thunbergia laurifolia Lindl. or Rang Chuet is a plant traditionally used in Thailand for the treatment of
toxicity and as an antidote for many poisons. This study aimed to investigate the effect of Rang Chuet
capsules on blood chemistry in 39 agricultural workers (21 males, 18 females) during an intensive 8-week
spraying program. The following tests were performed: serum butyrylcholinesterase (BChE) and serum
malondialdehyde (MDA) levels before and after Rang Chuet capsule supplementation. The results indicate
that serum BChE levels were unchanged in male and female workers. However, the levels of serum MDA
in male and female workers decreased significantly at p < 0.001 and p < 0.05, respectively. In this study, the
phylogenetic relationships within the large tropical and subtropical family Thunbergia were studied using
genomic DNA from the fresh leaves of sampled plants. The results showed 99% homology with Thunbergia
coccinea. This study indicates that Rang Chuet presents antioxidant activity and could be promoted as a
health supplement.

Author Biographies

Orapin Insuan

Lecturer, Department of Medical Technology, School of Allied Health Sciences, and Unit of Excellence in
Integrative Molecular Biomedicine, School of Allied Health Sciences, University of Phayao, Phayao, Thailand

Padchanee Sangthong

Assistant Professor Dr., Department of Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai,
Thailand

Pennipat Nabheerong

Lecturer, Department of Medicine, School of Medicine, University of Phayao, Phayao, Thailand

Surachat Buddhisa

Lecturer, Department of Medical Technology, Faculty of Allied Health Science, Burapha University, Chon Buri,Thailand

Peerawan Kengsangunsit

Researcher, Pak Kang Sub-District Health Promoting Hospital, Phrae, Thailand

Suntorn Prompao

Researcher, MaeJai Hospital, Phayao, Thailand

Benchaluk Thongchuai

Assistant Professor Dr, Department of Medical Technology, School of Allied Health Sciences, and Unit of Excellence in Integrative Molecular Biomedicine, School of Allied Health Sciences, University of Phayao, Phayao, Thailand

Published

2021-08-16

How to Cite

Orapin Insuan, Padchanee Sangthong, Pennipat Nabheerong, Surachat Buddhisa, Peerawan Kengsangunsit, Suntorn Prompao, & Benchaluk Thongchuai. (2021). Effect of Thunbergia Laurifolia Lindl. on Oxidative Stress and Blood Cholinesterase in farm Workers Exposed to Pesticides in the Mae Chai District of Phayao Province. Indian Journal of Forensic Medicine & Toxicology, 15(4), 2107-2113. https://doi.org/10.37506/ijfmt.v15i4.17014