Significant Association of Adam 33 Polymorphism with COPD in Javanese Population of Indonesia

Abstract

Background: Chronic Obstructive Pulmonary Disease (COPD) is one of World health cases that is commonly
known, which is triggered by the combination of environmental factors especially cigarette smoking and
genetic factors. The association between A disintegrin and metalloprotease 33 (ADAM33) polymorphisms
and COPD has been investigated and reported by other researchers. Objective: The main aim of this study is
to identify the association between single nucleotide polymorphisms (SNPs) in ADAM 33 gene with COPD
in the Javanese population in Lampung, Indonesia. Methods: A randomized cross-sectional study was used
in this research. PCR-Sequencing method was involved to analyze the polymorphic for three SNPs (T1, T2,
and Q-1) of the ADAM33 gene. Statistical analysis data was performed in descriptive and comparative as
well as it was measured by parametric/non-parametric tests. Results: The results showed that the T2 GG,
and T1AG genotypes in COPD group were significantly more frequent rather than in control group (p <
0.05). In case of allele, it was found that the T1G and T2G was higher in COPD group rather than in the
control group (p = 0.440 and 0.131, respectively). Conclusion: The results clearly conclude that there was
significant association between T1 and T2 polymorphisms of ADAM33 gene and COPD in the Javanese
population of Lampung, Indonesia.