Significant Association of Adam 33 Polymorphism with COPD in Javanese Population of Indonesia

Authors

  • Retno Ariza Soeprihatini Soemarwoto
  • Jamsari
  • Yanwirasti
  • Andika Chandra Putra
  • Syazili Mustofa
  • Wawan Abdullah Setiawan
  • Ifan Aulia Candra

DOI:

https://doi.org/10.37506/ijfmt.v15i4.17045

Keywords:

ADAM 33 gene polymorphism, COPD, smoking, Javanese, SNP

Abstract

Background: Chronic Obstructive Pulmonary Disease (COPD) is one of World health cases that is commonly
known, which is triggered by the combination of environmental factors especially cigarette smoking and
genetic factors. The association between A disintegrin and metalloprotease 33 (ADAM33) polymorphisms
and COPD has been investigated and reported by other researchers. Objective: The main aim of this study is
to identify the association between single nucleotide polymorphisms (SNPs) in ADAM 33 gene with COPD
in the Javanese population in Lampung, Indonesia. Methods: A randomized cross-sectional study was used
in this research. PCR-Sequencing method was involved to analyze the polymorphic for three SNPs (T1, T2,
and Q-1) of the ADAM33 gene. Statistical analysis data was performed in descriptive and comparative as
well as it was measured by parametric/non-parametric tests. Results: The results showed that the T2 GG,
and T1AG genotypes in COPD group were significantly more frequent rather than in control group (p <
0.05). In case of allele, it was found that the T1G and T2G was higher in COPD group rather than in the
control group (p = 0.440 and 0.131, respectively). Conclusion: The results clearly conclude that there was
significant association between T1 and T2 polymorphisms of ADAM33 gene and COPD in the Javanese
population of Lampung, Indonesia.

Author Biographies

Retno Ariza Soeprihatini Soemarwoto

Associate Professor, Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas
Lampung, Bandar Lampung, Indonesia

Jamsari

Professor, Department of Plant Breeding, Faculty of Agriculture,Universitas Andalas, 25136, Padang, Indonesia

Yanwirasti

Professor, Department of Anatomy, Faculty of Medicine,Universitas Andalas, Padang, Indonesia

Andika Chandra Putra

Medical Staff, Department of Pulmonology and Respiratory Medicine,Faculty of Medicine, Universitas Indonesia, National Respiratory Referral Persahabatan Hospital, Jakarta,Indonesia

Syazili Mustofa

Medical Staff, Department of Biochemistry, Molecular Biology and Physiology, Faculty of Medicine,
Universitas Lampung, Bandar Lampung, Indonesia

Wawan Abdullah Setiawan

Lecturer, Department of Biology Faculty of Mathematics and Natural Science, Universitas Lampung, Bandar Lampung, Indonesia

Ifan Aulia Candra

Staff, Department of Biotechnology, Post-Graduate Program, Universitas Andalas, Padang, Indonesia

Published

2021-08-16

How to Cite

Retno Ariza Soeprihatini Soemarwoto, Jamsari, Yanwirasti, Andika Chandra Putra, Syazili Mustofa, Wawan Abdullah Setiawan, & Ifan Aulia Candra. (2021). Significant Association of Adam 33 Polymorphism with COPD in Javanese Population of Indonesia. Indian Journal of Forensic Medicine & Toxicology, 15(4), 2264-2272. https://doi.org/10.37506/ijfmt.v15i4.17045

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