Physical Exercise in Clinical Stage IIhuman Immunodeficiency Virus Infection Patients’ Increasesskeletal Muscle MAss Through the Increasing of Myogenic Regulatory Factors Expression

Authors

  • Sri Mardjiati Mei Wulan
  • Hening Laswati
  • Usman Hadi
  • Nasronudin Nasronudin

DOI:

https://doi.org/10.37506/ijfmt.v15i4.17091

Keywords:

HIV, Rehabilitation Exercise, Myogenic Regularly Factors, Indonesia.

Abstract

Background: Human Immunodeficiency Virus infection is a chronic diseasethat threatensthe health ofmillions
of people inthe worldand causing disability. One of the factors that causedisabilityis HIVmusclewasting,
causing a decrease inthe quality of lifethat interferethe daily activitiesand evenincreased mortality. Proper
physical exercise is needed to prevent and treat muscle wasting.
Methods: This studyusinghuman subjectswithclinicalstageII HIVinfection. Subjectswere groupedinto two:
Intervention (n =9) that subjects whogetmoderate-intensity physicalexercise (HIVA) for 8weeks andControl (n
=9) as subjects wereobservedfor 8 weeks. Muscles samples were taken fromthe vastuslateralismusclebiopsies
that performed24 hoursafterthe lastphysical exercise,immunohistochemicalexaminationwithmonoclonal
antibodyanti-Pax7, anti-MyoD1 andanti-myogenin and measurement of thigh circumference.
Results: Therewere significant increase in regeneration of skeletal muscle in the intervention group
(increasing of Pax7, MyoD1 and myogenin) than the control groupand significant increase in quadriceps
muscles mass as measured by thigh circumference (p < 0.001).
Conclusion: HIVA physical exerciseof moderate intensityincreasesskeletal muscleregenerationinclinical
stageII HIVinfectionthroughthe increasingPax7, MyoD1, myogeninexpression and followed by an increase
of quadriceps muscles mass.

Author Biographies

Sri Mardjiati Mei Wulan

Lecturer at The Department of Physical Medicine and Rehabilitation, Faculty of Medicine Airlangga Univercity/Dr. Soetomo General Hospital, Surabaya Indonesia

Hening Laswati

Lecturer at The Department of Physical Medicine and Rehabilitation, Faculty of Medicine Airlangga Univercity/Dr. Soetomo General Hospital, Surabaya Indonesia

Usman Hadi

Lecturer at The Department of Internal Medicine, Faculty of Medicine Airlangga University/Dr. Soetomo General Hospital, Surabaya Indonesia

Nasronudin Nasronudin

Lecturer at The Department of Internal Medicine, Faculty of Medicine Airlangga University/Dr. Soetomo General Hospital, Surabaya Indonesia, Lecturer at Airlangga University Hospital, Faculty of Medicine Airlangga UniversitySurabaya Indonesia

Published

2021-08-16

How to Cite

Sri Mardjiati Mei Wulan, Hening Laswati, Usman Hadi, & Nasronudin Nasronudin. (2021). Physical Exercise in Clinical Stage IIhuman Immunodeficiency Virus Infection Patients’ Increasesskeletal Muscle MAss Through the Increasing of Myogenic Regulatory Factors Expression. Indian Journal of Forensic Medicine & Toxicology, 15(4), 2566-2573. https://doi.org/10.37506/ijfmt.v15i4.17091