Correlation Luteinizing Hormone (LH)/Follicle Stimulating Hormone (FSH) Ratio with Low Density Lipoprotein (LDL)/ High Density Lipoprotein (HDL) Ratio in Polycystic Ovarium Syndrome (PCOS) Patients

Abstract

The aim of this study is to analyze the correlation between the ratio of LH and FSH levels with LDL and
HDL cholesterol in PCOS patients. This study is an observational cross-sectional study. The population in
this study were women newly diagnosed with polycystic ovary syndrome who came to RSIA Ferina, RSIA
Lombok 22, Elizabeth Clinic and RSIA Putri Surabaya and Clinical Pathology Laboratory of dr. Soetomo
Surabaya. Examination of FSH, LH and LDL and HDL cholesterol levels on 27 specimens (stored frozen
serum) using the ICT (Accurate Intan Madya®, VEDALAB) and enzymatic colorimetric (Dimension EXL®,
Siemens) methods. Statistical analysis was performed using the Spearman and Pearson correlation test,
with a significance level of p <0.05. The results showed that there was a moderate positive correlation
between FSH and LDL cholesterol (r = 0.491, p = 0.009). Phenotype D of PCOS (non-hyperandrogenic
type) had a moderate negative correlation between the LH / FSH ratio and the LDL/HDL cholesterol level
ratio (r = -0.487, p <0.05). However, there was no relationship between the LH/FSH ratio and the ratio
of LDL/HDL cholesterol levels in all SOPK patients in this study. This study showed that phenotype D
PCOS patients (non-hyperandrogenic type) were less likely to have cardiovascular complications than other
phenotypic PCOS patients. Insulin resistance has a role in the risk of dyslipidemia in non-hyperandrogenic
PCOS patients.