A Woman with Tuberculosis Multidrug Resistance and QTc Prolongation Repetitive Interval: A Case Report

Authors

  • Tutik Kusmiati
  • Ni Made Mertaniasih
  • Johanes Nugroho Eko Putranto
  • Budi Suprapti
  • Soedarsono
  • Abdul Rahman Bahmid

DOI:

https://doi.org/10.37506/ijfmt.v15i4.17119

Keywords:

TB-MDR, QTc prolongation, Moxifloxacin

Abstract

Background : Prolonged QTc interval is one of the side effects of the short-regimen MDR-TB. QTc
prolongation is a risk factor for Torsades de pointes and is influenced by many factors. Case : 47-year-old
woman who was diagnosed with MDR-TB through GeneXpert examination and received short-regimen
MDR-TB. This patient experienced repeated QTc prolongation, with peak QTc interval 600 msec occurring
at 4th month with mild hypokalemia without clinical symptoms. The patient completed 9 months of shortregimen
therapy with improve chest x ray followed by negative sputum culture. Conclusion : Short-regimen
MDR-TB contains several drugs that cause QTc prolongation. Clinical evaluation is required in patients
with QTc prolongation before changing the regiment.

Author Biographies

Tutik Kusmiati

Medical Staff, Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Airlangga– Dr. Soetomo General Academic Hospital, Surabaya, Indonesia

Ni Made Mertaniasih

Professor, Department of Medical Microbiology,Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Johanes Nugroho Eko Putranto

Associate Professor, Department of Vascular and Cardiology Medicine, Faculty of Medicine, Universitas Airlangga – Dr. Soetomo General Academic Hospital,Surabaya, Indonesia

Budi Suprapti

Associate Professor, Faculty of Pharmacy, Universitas Airlangga – Universitas Airlangga
Teaching Hospital, Surabaya, Indonesia

Soedarsono

Associate Professor, Department of Pulmonology and RespiratoryMedicine, Universitas Airlangga – Universitas Airlangga Teaching Hospital, Surabaya, Indonesia

Abdul Rahman Bahmid

Resident, Pulmonology and Respiratory Medicine, Universitas Airlangga – Universitas Airlangga
Teaching Hospital, Surabaya, Indonesia

Published

2021-08-16

How to Cite

Tutik Kusmiati, Ni Made Mertaniasih, Johanes Nugroho Eko Putranto, Budi Suprapti, Soedarsono, & Abdul Rahman Bahmid. (2021). A Woman with Tuberculosis Multidrug Resistance and QTc Prolongation Repetitive Interval: A Case Report. Indian Journal of Forensic Medicine & Toxicology, 15(4), 2748-2753. https://doi.org/10.37506/ijfmt.v15i4.17119

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