A Woman with Tuberculosis Multidrug Resistance and QTc Prolongation Repetitive Interval: A Case Report

Authors

  • Tutik Kusmiati
  • Ni Made Mertaniasih
  • Johanes Nugroho Eko Putranto
  • Budi Suprapti
  • Soedarsono
  • Abdul Rahman Bahmid

DOI:

https://doi.org/10.37506/ijfmt.v15i4.17119

Keywords:

TB-MDR, QTc prolongation, Moxifloxacin

Abstract

Background : Prolonged QTc interval is one of the side effects of the short-regimen MDR-TB. QTc
prolongation is a risk factor for Torsades de pointes and is influenced by many factors. Case : 47-year-old
woman who was diagnosed with MDR-TB through GeneXpert examination and received short-regimen
MDR-TB. This patient experienced repeated QTc prolongation, with peak QTc interval 600 msec occurring
at 4th month with mild hypokalemia without clinical symptoms. The patient completed 9 months of shortregimen
therapy with improve chest x ray followed by negative sputum culture. Conclusion : Short-regimen
MDR-TB contains several drugs that cause QTc prolongation. Clinical evaluation is required in patients
with QTc prolongation before changing the regiment.

Author Biographies

  • Tutik Kusmiati

    Medical Staff, Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Airlangga– Dr. Soetomo General Academic Hospital, Surabaya, Indonesia

  • Ni Made Mertaniasih

    Professor, Department of Medical Microbiology,Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

  • Johanes Nugroho Eko Putranto

    Associate Professor, Department of Vascular and Cardiology Medicine, Faculty of Medicine, Universitas Airlangga – Dr. Soetomo General Academic Hospital,Surabaya, Indonesia

  • Budi Suprapti

    Associate Professor, Faculty of Pharmacy, Universitas Airlangga – Universitas Airlangga
    Teaching Hospital, Surabaya, Indonesia

  • Soedarsono

    Associate Professor, Department of Pulmonology and RespiratoryMedicine, Universitas Airlangga – Universitas Airlangga Teaching Hospital, Surabaya, Indonesia

  • Abdul Rahman Bahmid

    Resident, Pulmonology and Respiratory Medicine, Universitas Airlangga – Universitas Airlangga
    Teaching Hospital, Surabaya, Indonesia

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Published

2021-08-16

Issue

Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology

Section

Articles

License

https://creativecommons.org/licenses/by-nc/2.0/deed.en

How to Cite

A Woman with Tuberculosis Multidrug Resistance and QTc Prolongation Repetitive Interval: A Case Report. (2021). Indian Journal of Forensic Medicine & Toxicology, 15(4), 2748-2753. https://doi.org/10.37506/ijfmt.v15i4.17119