A Comparison Study of Adding Magnesium Sulfate to Local Anesthetics During Spinal Anesthesia for Cesarean Section

Abstract

Background: Regional anesthesia is frequently used in obstetric, orthopedic, and urological procedures,
commonly intrathecal and epidural local anesthetics are combined with opioids to prolong analgesia; however,
these do not prolong the motor block time and can attenuate the response to surgical stress, in addition to
being associated with side effects such as respiratory depression, urinary retention, pruritus, hemodynamic
instability, nausea, and emesis. Objective: to investigate the effect of adding 75 mg ofmagnesium sulfate on
the duration of sensory block and duration of motor block
Patients and Methods: In a prospective randomized study, ASA I or II, 128 (64 control and 64 experimental
groups) pregnant women (at term) who were candidate for cesarean section with spinal anesthesia, were
recruited in this study. They were collected from “Baghdad Teaching Hospital” at the period from (September
2020 to Fab 2021).
Each experimental woman received 12.5 mg (2.5 ml) of hyperbaric bupivacaine
(0.5%) and 0.5 ml (75 mg) magnesium sulfate (15%), while controls received same does of hyperbaric
bupivacaine and 0.5 ml of distilled water.
Results: The duration of analgesia (sensory blockade) and theduration of motor blockade manifested
a statistically significant increase inexperimental as compared to their controls (control = 116.41 ±
12.47,experimental = 159.75 ± 10.56, control = 180.76 ± 11.83, experimental = 240 ±9.46 minutes
respectively).
Conclusion:Significantly increased the duration ofpostoperative analgesia and prolonged the sensory and
motor blockade withoutsignificant apparent maternal or fetal side effects.