Evaluation of the PaO2/FiO2 Ratio as a Risk Factor for Hypoxemia against Septicemia Mortality in Children who Treated at Dr. Soetomo General Hospital
DOI:
https://doi.org/10.37506/ijfmt.v15i4.17142Keywords:
Septicemia; P/F ratio; children; hypoxemiaAbstract
Background: Severe septicemia can result in impaired oxygen perfusion to the tissues. The PaO2/FiO2 ratio
(P/F ratio) is one of the measurement parameters for hypoxemia. This study aims to evaluate the P/F ratio as
a risk factor for hypoxemia against septicemia mortality in children.
Method: An observational with a prospective cohort design was conducted. Thirty-six patients with
septicemia, consisting of 18 patients who living (survivor) and 18 patients who died (non-survivor). The
P/F ratio is obtained based on blood gas analysis carried out in the first 24 hours of treatment recorded on
medical records and calculated manually. The P/F ratio has an area under the curve (AUC) of 0.83 (95%
CI 0.71–0.95) with a cut-off of 226. Septicemia children with P/F ratio < 226 who have a mortality risk
of up to 6.9 times (RR 6.9; 95% CI 1.719-27.957; p= 0.005) with sensitivity 72.70%; specificity 72.20%;
PPV 76.19%; NPV 68.42%. The mean P/F ratio in the non-survivor group was significantly lower than the
survivor group 161.60 (95% CI 1.05) compared to 391.09 (95% CI 2.13); p= 0.005).
Conclusion: The P/F ratio can be a risk factor for hypoxemia on septicemia mortality.
Downloads
Published
How to Cite
Issue
Section
License
- The journal allows readers to read, download, copy, distribute, print, search, or link to the full texts of its articles and allow readers to use them for any other lawful purpose.
- The journal allows the author(s) to hold the copyright without restrictions.
- The journal allows the author(s) to retain publishing rights without restrictions