Molecular Detection of BK Polyomavirus in Patients Under Hemodialysis

Abstract

The study was conducted in Kirkuk city-Iraq from of February 2018 to September 2018. The number
of chronic kidney disease patients under study were 60 patients whose ages were between 40-70 years
old. These patients admitted to Kirkuk general hospital (hemodialysis unit). The control group who
were matched to the patients studied, included 30 healthy blood donor and their ages were between 30-
75 years old. Blood samples were collected for detection of BK polyomavirus DNA by real time-PCR.
The study showed that the highest rate of BK polyomavirus DNA occurrence were recorded in patients
with chronic kidney disease when compared with control group (51.66% versus 3.33%) (P: <0.01).
The study showed that the highest mean level of IL-6 was recorded in patients with chronic kidney
disease comparing with the control group (78.42 v.s. 3.40 ng/ml). The result was highly significant. The
present study demonstrated that the highest mean level of IL-6 was found in prostates cancer patients
who were positive to BK polyomavirus DNA comparing with BK polyomavirus DNA negative (52.54
versus 25.88 ng/ml)
It was concluded that BK polyomavirus was frequently detected in chronic kidney disease patients and
could play a relevant role in the development and progression of human hemodialysis