Study of Lipid Profile, Lipid Peroxidation and DNA Damage in Patients with Coronary Artery Disease

Authors

  • Ahmed Jabbar AL Jabbiry
  • Kadhum J. Gattia
  • Hazim I. Abd Albari

DOI:

https://doi.org/10.37506/ijfmt.v16i1.17442

Keywords:

Coronary artery disease, DNA damage, Antioxidant, Lipid profile.

Abstract

Background and Objective: This study was conducted to investigate some clinical aspects of coronary
artery patients, as it included some tests for lipid oxidation and DNA damage and the extent of their
association with the risk of coronary artery disease in the Iraqi population. Results: The lipid showed
significant differences between the preferred messages in measuring lipids, TG (P = 0.005), highdensity
lipoprotein P = 0.018 (HDL) and low-density lipoprotein (vLDL) P = 0.004. It was named in
lipid profile, and it was named In seizure patients (nonSTEMI). The glutathione analysis showed a
significant decrease in patients compared to healthy subjects, and the unstable, non-Stemi and Stemiseries
results were significant, and the significant differences were at (P = 0.00036). As for the research
results, the significant differences were when they were high (P = 0.00072). The results of the comet
assay showed differences between the four groups, for the group of patients with unstable angina and
who suffer from a heart attack (Non-Stemi), the results showed close to average levels in the genetic
material (P = 0.00014). The highest damage in the genetic material of patients with coronary artery
disease was in patients suffering from a heart attack (Stemi) where the level of significant damage was
very large compared to the rest of the groups (P = 0.00025). The results obtained on the biochemical
levels of GHs, VLDL, HDL, TG and MDA showed significant differences between the healthy and the
groups of patients with coronary artery disease below the probability level (P> 0.05). Also, the incidence
of DNA damage in patients with coronary artery disease is much greater than healthy patients, and this
indicates a significant effect of DNA damage on blood vessels, and on the other hand, STEMI patients
are the most vulnerable to infection.

Author Biographies

Ahmed Jabbar AL Jabbiry

Final Year Post Graduate Student Biology Dept. College of Science. University of Wasit,Iraq-Wasit

Kadhum J. Gattia

Professor, Biology Dept. College of Science. University of Wasit,Iraq-Wasit

Hazim I. Abd Albari

Professor, Biotechnology Center, Al-Nahrin University, Al-Jadriya campus,10071 Baghdad, Iraq

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Published

2021-11-02

How to Cite

Ahmed Jabbar AL Jabbiry, Kadhum J. Gattia, & Hazim I. Abd Albari. (2021). Study of Lipid Profile, Lipid Peroxidation and DNA Damage in Patients with Coronary Artery Disease. Indian Journal of Forensic Medicine & Toxicology, 16(1), 155–161. https://doi.org/10.37506/ijfmt.v16i1.17442