Vascular Endothelial Growth Factor (VEGF) Expression on Placenta Accreta Spectrum (PAS) FIGO Grading

Authors

  • Ana Puji Rahayu
  • Agus Sulistyono
  • Ernawati
  • Grace Ariani
  • Rozi Aditya Aryananda

DOI:

https://doi.org/10.37506/ijfmt.v16i1.17455

Keywords:

Grading, placenta accreta, VEGF

Abstract

This study aims to analyze the role of placenta VEGF level using immunocytochemical techniques and
comparing the obtained results with PAS FIGO grading. This retrospective cross sectional study on
total sampling of formalin fixed paraffin-embedded tissue from placenta sampling of elective surgery
which were diagnosed as PAS. Sample were immunostained using VEGF and semi-quantitatively
Immuno Reactive Score (IRS) measured based on modified Remmele scale index. The result obtained
32 samples that meet inclusion criteria which are found into grade I (n=5), grade II (n=11) and grade
III (n=16). This study showed average VEGF at grade I (4.68±1.03), grade II (3.81±1.41), grade III
(4.46±1.82) and no significant difference of VEGF expression between grade I, grade II and grade III
(p = 0.264). Intraplacental VEGF do not describe the severity of PAS FIGO grading.

Author Biographies

Ana Puji Rahayu

Resident, Department of Obstetrics and Gynecology, Faculty of Medicine, Airlangga University, Surabaya,
Indonesia, Resident, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia,

Agus Sulistyono

Lecturer, Department of Obstetrics and Gynecology ,Lecturer, Dr. Soetomo General Academic Hospital, Surabaya,Indonesia

Ernawati

Lecturer, Department of Obstetrics and Gynecology ,Lecturer, Dr. Soetomo General Academic Hospital, Surabaya,Indonesia

Grace Ariani

Lecturer, Department of Anatomical Pathology, Faculty of Medicine, Airlangga University, Surabaya, Indonesia, 5Lecturer, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia

Rozi Aditya Aryananda

Lecturer, Department of Obstetrics and Gynecology ,Lecturer, Dr. Soetomo General Academic Hospital, Surabaya,Indonesia

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Published

2021-11-30

How to Cite

Ana Puji Rahayu, Agus Sulistyono, Ernawati, Grace Ariani, & Rozi Aditya Aryananda. (2021). Vascular Endothelial Growth Factor (VEGF) Expression on Placenta Accreta Spectrum (PAS) FIGO Grading. Indian Journal of Forensic Medicine & Toxicology, 16(1), 224–229. https://doi.org/10.37506/ijfmt.v16i1.17455