Alpha-Mangostin and Gamma-Mangostin Isolated from Mangosteen (Garcinia mangostana L.) as Promising Candidates against SARS-CoV-2: A Bioinformatics Approach

Authors

  • Arif Nur Muhammad Ansori

DOI:

https://doi.org/10.37506/ijfmt.v16i1.17461

Keywords:

Alpha-mangostin, COVID-19, Gamma-mangostin, Garcinia mangostana L., SARS-CoV-2

Abstract

The world is endangered by the COVID‐19 pandemic caused by SARS‐CoV‐2, people are dying in
thousands every day, and without an actual treatment, it seems that bringing this global health problem
to a quit is impossible. Natural products have been in constant use since ancient times and are proven
by time to be effective. Medicinal plants from Indonesia may lead to the discovery of the novel drugs.
Mangosteen or Garcinia mangostana L. is a native tropical fruit from Southeast Asia and is known to
contain bioactive compounds. Interestingly, the main xanthone derivatives are alpha-mangostin and
gamma-mangostin, these compounds have a variety of pharmacological activities such as antiviral
activity. In summary, this study showed potential pharmacological benefits of alpha-mangostin and
gamma-mangostin isolated from mangosteen against SARS-CoV-2. Thus, mangosteen exhibits as a
valuable plant and a candidate for future drug development to fight SARS-CoV-2. However, further
trials, such as in vitro and in vivo evaluation, are needed to prove the validity of these findings

Author Biography

Arif Nur Muhammad Ansori

Doctoral Student, Doctoral Program in Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, Indonesia

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Published

2021-11-30

How to Cite

Arif Nur Muhammad Ansori. (2021). Alpha-Mangostin and Gamma-Mangostin Isolated from Mangosteen (Garcinia mangostana L.) as Promising Candidates against SARS-CoV-2: A Bioinformatics Approach . Indian Journal of Forensic Medicine & Toxicology, 16(1), 251–258. https://doi.org/10.37506/ijfmt.v16i1.17461