Physical and Psychological Stressor Exposure during Pregnancy Impacts the Expression of Synapsin and Neuronal Cells Number of MUS Musculus Offspring
Keywords:Cerebrum, neurons, pregnancy, stress, synapsin
Introduction: Stress during gestation can lead to inappropriate fetal brain development, especially
psychological stress. Psychological stress play pivotal role in offsprings’ brain development.
Objective: The aim of this study was to investigate the effects of maternal exposure to physical and
psychological stress during pregnancy on the cerebrum in mice offspring.
Method: This study was an analytical experiment study with the subject were 24 female mice Mus
musculus. The sample were divided into treatment and control group. Treatment groups divided into
three conditions, 1 group was given physical stress, 1 group with psychological stress, and 1 group
was given combination of physical and psychological stress intervention. The data were analyzed with
ANOVA test then followed by LSD to find the differences between all groups.
Results: The ANNOVA test results showed significant differences of the expression of synapsin with
p = 0.0000. The number of neuronal cells also represented significant differences with p = 0.000 on the
Conclusion: Stress exposure during pregnancy can induce bad impacts in brain development, especially
the expression of synapsin and the number of neuronal cells on the cerebrum in mice offspring.
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