Physical and Psychological Stressor Exposure during Pregnancy Impacts the Expression of Synapsin and Neuronal Cells Number of MUS Musculus Offspring

Authors

  • Diana Estu Rumahastuti
  • Hermanto Tri Joewono
  • Widjiati

DOI:

https://doi.org/10.37506/ijfmt.v16i1.17482

Keywords:

Cerebrum, neurons, pregnancy, stress, synapsin

Abstract

Introduction: Stress during gestation can lead to inappropriate fetal brain development, especially
psychological stress. Psychological stress play pivotal role in offsprings’ brain development.
Objective: The aim of this study was to investigate the effects of maternal exposure to physical and
psychological stress during pregnancy on the cerebrum in mice offspring.
Method: This study was an analytical experiment study with the subject were 24 female mice Mus
musculus. The sample were divided into treatment and control group. Treatment groups divided into
three conditions, 1 group was given physical stress, 1 group with psychological stress, and 1 group
was given combination of physical and psychological stress intervention. The data were analyzed with
ANOVA test then followed by LSD to find the differences between all groups.
Results: The ANNOVA test results showed significant differences of the expression of synapsin with
p = 0.0000. The number of neuronal cells also represented significant differences with p = 0.000 on the
cerebrum.
Conclusion: Stress exposure during pregnancy can induce bad impacts in brain development, especially
the expression of synapsin and the number of neuronal cells on the cerebrum in mice offspring.

Author Biographies

Diana Estu Rumahastuti

Posgraduate Student of Reproductive Health Science, Faculty of Medicine Universitas Airlangga, Surabaya,
Indonesia

Hermanto Tri Joewono

Lecturer at Department of Obstetry and Gynecology, Faculty of Medicine Universitas Airlangga/
RSU Dr. Soetomo, Surabaya, Indonesia,

Widjiati

Professor at Department of Embriology, Faculty of Veterinary Medicine Universitas Airlangga, Surabaya, Indonesia

Downloads

Published

2021-11-30

How to Cite

Diana Estu Rumahastuti, Hermanto Tri Joewono, & Widjiati. (2021). Physical and Psychological Stressor Exposure during Pregnancy Impacts the Expression of Synapsin and Neuronal Cells Number of MUS Musculus Offspring. Indian Journal of Forensic Medicine & Toxicology, 16(1), 366–372. https://doi.org/10.37506/ijfmt.v16i1.17482