Qualitative Analysis of Cinnamomum burmannii Content using GCMS (Gas Chromatography Mass Spectometry) Method

Authors

  • Hayati
  • Jusak Nugraha
  • Bambang Purwanto
  • Hari Basuki Notobroto
  • Yoes Prijatna Dachlan
  • Hari Setiono
  • Idha Kusumawati

DOI:

https://doi.org/10.37506/ijfmt.v16i1.17556

Keywords:

Cinnamomum burmannii, antifungal, antibacterial, antioxidant, anti-inflammatory, antineoplastic.

Abstract

To identify the bioactive compounds in Cinnamomum burmannii and their biological activity. Cinnamon
bark originating from Batu Malang, East Java, which was located 700-1300 meters above sea level, was
processed into dry extract by maceration method with 96% ethanol solvent. Furthermore, cinnamon
ethanol extract was analyzed using the GCMS method to look at the content of the bioactive component
for further testing biological activity with the server Way2Drug PASS. GCMS results showed 40 active
compounds such as trans-cinnamaldehyde, trans-anethole, cinnamyl acetate, calacorene, cadina-1,
4-diene, delta-cadinene. Furthermore, of the 40 compounds, the biological activity potential was tested
for 29 bioactive compounds based on PA (probable to be active) values predicted by the Way2Drug
PASS server. Cinnamomum was tested against the potential as anti-fungi, anti-bacterial, anti-oxidant,
anti-inflammatory, anti-diabetic, anti-neoplastic. Trans-cinnamaldehyde showed PA 0,583 as anti
inflammatory, L-limonene PA0,818 as anti neoplastic, Tans-anethole PA 0,614 as anti neoplastic,
Cinnamyl acetate PA 0,669 as anti inflammatory, calacorene PA 0,698 as anti inflammatory, Deltacadinene
PA 0,651 as anti neoplastic, , Cathechin PA 0,828 as anti oxidant, alpha.-Cubebene PA 0,888 as
anti inflammatory and PA 0,837 as anti neoplastic, melilotin PA 0,929 as anti neoplastic, Caryophyllene
PA0,915 as anti neoplastic. Cinnamomum burmannii had biological potency based on potential activity
(PA) 0,432 (+0,117) as antifungi, PA 0,335 (+0,090) as antibacterial, PA 0,304 (+0,199) as antioxidan,
PA 0,561 (+0,190) as anti inflammatory, PA 0,373 (+0,170) as antidiabetic, PA 0,584 (+0,234) as
antineoplastic.

Author Biographies

Hayati

Lecturer, Universitas PGRI Adi Buana, Surabaya, Indonesia, Student, Doctoral Program, Faculty
of Medicine, Universitas Airlangga, Surabaya, Indonesia,

Jusak Nugraha

Lecturer, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia,

Bambang Purwanto

Lecturer, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Hari Basuki Notobroto

Lecturer, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia, Lecturer, Faculty of Public Health, Universitas Airlangga Surabaya, Indonesia

Yoes Prijatna Dachlan

Lecturer, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Hari Setiono

Lecturer, Sports Science Faculty, Universitas Negeri Surabaya, Indonesia

Idha Kusumawati

Lecturer, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia

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Published

2021-11-30

How to Cite

Hayati, Jusak Nugraha, Bambang Purwanto, Hari Basuki Notobroto, Yoes Prijatna Dachlan, Hari Setiono, & Idha Kusumawati. (2021). Qualitative Analysis of Cinnamomum burmannii Content using GCMS (Gas Chromatography Mass Spectometry) Method. Indian Journal of Forensic Medicine & Toxicology, 16(1), 570–575. https://doi.org/10.37506/ijfmt.v16i1.17556