Relationship between Neutrophil-Lymphocyte Ratio and Disease Severity in COVID-19 Patients in Isolation Ward of Dr. Soetomo General Teaching Hospital

Authors

  • Heri Krisnata Ginting
  • M. Vitanata Arfijanto
  • Tri Pudy Asmarawati
  • S. Ugroseno Yudho Bintoro

DOI:

https://doi.org/10.37506/ijfmt.v16i1.17558

Keywords:

COVID-19, neutrophil lymphocytes ratio, risk-factors, clinical characteristics.

Abstract

This study was conducted to prove the relationship between the neutrophil-lymphocyte ratio and the
severity of COVID-19. A retrospective cohort study using medical record data of inpatients from June
to July 2020. Analysis of the NLR relationship and the degree of severity using the Mann Whitney test
if the data had an abnormal distribution. Significant if p<0.05 and 95% confidence interval. If there were
significant results, we try to measure the cut-off of NLR value to predict severe and non-severe clinical
symptoms. Total study subjects were 110 patients, with a male as many as 65 (59.1%), the median age
was 53.5 years (range 20-88). Most of the comorbidities were diabetes mellitus (35.5%), followed by
hypertension (30%). The severity of clinical symptoms was 50% in the non-severe and severe groups,
respectively. The NLR value was higher in the severe group. Mann-Whitney test showed significant
differences in the value of NLR between the severe group and the not severe group with the p-value
<0.001. Receiver operating characteristic (ROC) curve analysis area under the curve (AUC) of NLR
on day-1 was 0.716 (CI 95%: 0.605 - 0.826), and the cut-off point of the prediction severity disease
at day-7 was ≥ 6.14 with a sensitivity of 71% and a specificity of 69.1%. The neutrophil-lymphocyte
ratio value with severe symptoms was higher than the neutrophil ratio value for lymphocytes with nonsevere
symptoms in patients with COVID-19.

Author Biographies

Heri Krisnata Ginting

Resident, Internal Medicine, Faculty of Medicine, Faculty of Medicine, Airlangga University, Dr. Soetomo General Hospital, Surabaya, Indonesia

M. Vitanata Arfijanto

Lecturer, Division of Tropical Diseases and Infections -Department of Internal Medicine, Faculty of Medicine, Airlangga University, Dr. Soetomo General Hospital, Surabaya, Indonesia

Tri Pudy Asmarawati

Lecturer, Division of Tropical Diseases and Infections - Department of Internal Medicine, Faculty of Medicine, Airlangga University, Dr. Soetomo General Hospital, Surabaya, Indonesia

S. Ugroseno Yudho Bintoro

Lecturer, Division of Medical Oncology Hematology- Department of Internal Medicine, Faculty of Medicine, Airlangga University, Dr. Soetomo General Hospital, Surabaya, Indonesia

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Published

2021-11-30

How to Cite

Heri Krisnata Ginting, M. Vitanata Arfijanto, Tri Pudy Asmarawati, & S. Ugroseno Yudho Bintoro. (2021). Relationship between Neutrophil-Lymphocyte Ratio and Disease Severity in COVID-19 Patients in Isolation Ward of Dr. Soetomo General Teaching Hospital. Indian Journal of Forensic Medicine & Toxicology, 16(1), 589–597. https://doi.org/10.37506/ijfmt.v16i1.17558