Diagnostic Value of Mid Regional Proadrenomedullin as a Sepsis Biomarker in Pediatric Patients with Cancer-Related Chemotherapy
Keywords:Cancer, chemotherapy, diagnostic, mid regional proadrenomedullin, pediatric, sepsis
The aim of this study was to analyze the diagnostic value of mid regional proadrenomedullin as a sepsis
biomarker in pediatric patients with cancer-related chemotherapy. This cross-sectional observational
study was located in General Hospital Dr. Soetomo Surabaya from September until December 2020.
International Pediatric Sepsis Consensus Conference criteria was used to define sepsis term on 2 study
groups. Serum mid regional proadrenomedullin has been drawn from 60 subjects (41 in-ward pediatric
patients) and measured on sandwich enzyme-linked immunosorbent assay from Elabscience® Human
Mid Regional Proadrenomedullin. Humareader Single Plus® was used to measure the optical density.
ROC analysis was used to find out cut off value, sensitivity, specificity, positive predictive value, negative
predictive value, negative likelihood ratio, positive likelihood ratio, and accuracy, respectively. Statistics
declared significant if p<0.05 (95% CI). Between groups, temperature and heart rate were statistically
different (p<0.001; 95% CI). The median difference of mid regional proadrenomedullin between groups
was significant (p<0.05; 95% CI). Cut off value 2,88 nmol/L, sensitivity 60.0%, specificity 56.67%,
positive predictive value 58.06%, negative predictive value 58.62%, positive likelihood ratio 1.38,
negative likelihood ratio 0.71 and diagnostic accuracy 59.33% was obtained while area under curve
was 0.707, respectively. Sepsis in children with cancer –related chemotherapy has not well diagnosed
by serum mid regional proadrenomedullin.
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