Diagnostic Value of Mid Regional Proadrenomedullin as a Sepsis Biomarker in Pediatric Patients with Cancer-Related Chemotherapy

Authors

  • Joko Susanto
  • Muhammad Robiul Fuadi
  • Mia Ratwita Andarsini

DOI:

https://doi.org/10.37506/ijfmt.v16i1.17569

Keywords:

Cancer, chemotherapy, diagnostic, mid regional proadrenomedullin, pediatric, sepsis

Abstract

The aim of this study was to analyze the diagnostic value of mid regional proadrenomedullin as a sepsis
biomarker in pediatric patients with cancer-related chemotherapy. This cross-sectional observational
study was located in General Hospital Dr. Soetomo Surabaya from September until December 2020.
International Pediatric Sepsis Consensus Conference criteria was used to define sepsis term on 2 study
groups. Serum mid regional proadrenomedullin has been drawn from 60 subjects (41 in-ward pediatric
patients) and measured on sandwich enzyme-linked immunosorbent assay from Elabscience® Human
Mid Regional Proadrenomedullin. Humareader Single Plus® was used to measure the optical density.
ROC analysis was used to find out cut off value, sensitivity, specificity, positive predictive value, negative
predictive value, negative likelihood ratio, positive likelihood ratio, and accuracy, respectively. Statistics
declared significant if p<0.05 (95% CI). Between groups, temperature and heart rate were statistically
different (p<0.001; 95% CI). The median difference of mid regional proadrenomedullin between groups
was significant (p<0.05; 95% CI). Cut off value 2,88 nmol/L, sensitivity 60.0%, specificity 56.67%,
positive predictive value 58.06%, negative predictive value 58.62%, positive likelihood ratio 1.38,
negative likelihood ratio 0.71 and diagnostic accuracy 59.33% was obtained while area under curve
was 0.707, respectively. Sepsis in children with cancer –related chemotherapy has not well diagnosed
by serum mid regional proadrenomedullin.

Author Biographies

Joko Susanto

Resident, Clinical Pathology,Faculty of Medicine, Airlangga University - Dr. Soetomo General Hospital, Surabaya, Indonesia

Muhammad Robiul Fuadi

Lecturer, Department of Clinical Pathology, Faculty of Medicine, Airlangga University - Dr. Soetomo General Hospital, Surabaya, Indonesia

Mia Ratwita Andarsini

Lecturer, Department of Pediatrics, Faculty of Medicine, Airlangga University - Dr. Soetomo General Hospital, Surabaya, Indonesia

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Published

2021-11-30

How to Cite

Joko Susanto, Muhammad Robiul Fuadi, & Mia Ratwita Andarsini. (2021). Diagnostic Value of Mid Regional Proadrenomedullin as a Sepsis Biomarker in Pediatric Patients with Cancer-Related Chemotherapy. Indian Journal of Forensic Medicine & Toxicology, 16(1), 658–663. https://doi.org/10.37506/ijfmt.v16i1.17569