Hippocampal Volume and Entorhinal Cortex Thickness in Alzheimer’s Disease

Authors

  • Leon Agung Manurung
  • Widiana Ferriastuti
  • Bambang Soeprijanto
  • Hartono Yudi Sarastika

DOI:

https://doi.org/10.37506/ijfmt.v16i1.17577

Keywords:

Alzheimer’s Disease, Head MRI, Hippocampus, Entorhinal Cortex

Abstract

Magnetic Resonance Imaging (MRI) is the standard imaging evaluations in Alzheimer’s Disease (AD).
Information regarding hippocampus and entorhinal cortex sizes plays an important role in Alzheimer’s
disease. This study aims to determine hippocampal volume and entorhinal cortex thickness in
Alzheimer’s disease obtained from a group of patients who underwent head MRI.
This study was an observational study with retrospective approach in patients who were diagnosed
with AD and had available head MRI examination results. A total of 14 patients were diagnosed by a
neurologist with AD using MMSE, Hachinsky, and NIA-AA criteria.
From head MRI measurement in AD patients, we found that the mean volume of right, left, and
total hippocampal was 1700±0.395 cm3; 1.670±0.349 cm3; and 3.370±0.725 cm3, respectively. The
mean thickness of right, left, and total entorhinal cortex was 1.821±0.459 mm; 1.463±0.369 mm; and
3.285±0.791 mm, respectively. There is a possible difference between the early and late stages of AD in
the same patient. Further studies with larger cohorts are needed to examine these correlations.

Author Biographies

Leon Agung Manurung

Resident, Department of Radiology, Faculty of Medicine, Airlangga University, Surabaya, Indonesia

Widiana Ferriastuti

Staff, Department of Radiology, Faculty of Medicine, Airlangga University, Surabaya, Indonesia

Bambang Soeprijanto

Staff, Department of Radiology, Faculty of Medicine, Airlangga University, Surabaya, Indonesia

Hartono Yudi Sarastika

Staff, Department of Radiology, Faculty of Medicine, Airlangga University, Surabaya, Indonesia

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Published

2021-11-30

How to Cite

Leon Agung Manurung, Widiana Ferriastuti, Bambang Soeprijanto, & Hartono Yudi Sarastika. (2021). Hippocampal Volume and Entorhinal Cortex Thickness in Alzheimer’s Disease. Indian Journal of Forensic Medicine & Toxicology, 16(1), 720–726. https://doi.org/10.37506/ijfmt.v16i1.17577