Galactooligosaccharide (GOS) Fortified Formula Feeding in Premature Infants

Authors

  • Martono Tri Utomo
  • Muhammad Reza
  • Risa Etika
  • Talitha Y. Aden
  • Iwan S. Handoko
  • Ruth A. Alexander

DOI:

https://doi.org/10.37506/ijfmt.v16i1.17587

Keywords:

Formula feeding; Oligosaccharides supplementation; low birth weight infant; premature

Abstract

Background: Nutritional problems are one of the serious problems in low birth weight or preterm
infants. This causes medical and nutrition management of premature infants to be more individual.
Objective: To evaluate the outcome of the premature infants with Galactooligosaccharides (GOS)
fortified formula feeding
Methods: This was prospective, open label cohort study that conducted during March- December 2019
in Neonatology Unit at the one of the main referral hospitals in East Java, Indonesia. The population
of the study was very low birth weight infants (1,000 g - ≤1,500g) who needed formula feeding. Weight,
body length, head circumference, fecal models and the incidence of diarrhea, colic, regurgitation, and
vomiting was observed. Patients were observed for 28 days or adjusted according to length of stay.
Results: Totally, 20 infants were included. Mean birth weight was 1236.2±148.5 grams. Mean total
volume Galactooligosaccharides fortified formula at the start of recruitment was 209.4±46.1 ml and
at the end of observation was 267.9±41.2 ml. There were change in amount and consistency of feces
before and after intervention. No patient experienced adverse events (diarrhea, colic, regurgitation or
vomiting) while consuming Galactooligosaccharides fortified formula.

Conclusion: Galactooligosaccharides fortified formula in premature infant formula did not have a
detrimental effect on premature infants and did not cause intolerance

Author Biographies

Martono Tri Utomo

Tutor, Pediatrician, Department of Child Health, Faculty of Medicine, Airlangga University , Jl. Mayjen Prof. Dr. Moestopo No.6-8, Surabaya, Indonesia

Muhammad Reza

Pediatrician, Neonatology Consultant Department of Child Health, Faculty of Medicine, Airlangga University , Jl. Mayjen Prof. Dr. Moestopo No. 6-8, Surabaya, Indonesia

Risa Etika

Kalbe Nutritional Research Center, Gedung Graha Kirana Lt. 5 Suite 501, Jl. Yos Sudarso Kav. 88, Jakarta Utara, Indonesia

Talitha Y. Aden

General Practitioner,Department of Child Health, Faculty of Medicine, Airlangga University , Jl. Mayjen Prof. Dr. Moestopo No.6-8, Surabaya, Indonesia

Iwan S. Handoko

Researcher,Department of Child Health, Faculty of Medicine, Airlangga University , Jl. Mayjen Prof. Dr. Moestopo No.6-8, Surabaya, Indonesia,

Ruth A. Alexander

Researcher,Department of Child Health, Faculty of Medicine, Airlangga University , Jl. Mayjen Prof. Dr. Moestopo No.6-8, Surabaya, Indonesia,

Downloads

Published

2021-11-30

How to Cite

Martono Tri Utomo, Muhammad Reza, Risa Etika, Talitha Y. Aden, Iwan S. Handoko, & Ruth A. Alexander. (2021). Galactooligosaccharide (GOS) Fortified Formula Feeding in Premature Infants. Indian Journal of Forensic Medicine & Toxicology, 16(1), 763–770. https://doi.org/10.37506/ijfmt.v16i1.17587