Height-for-age in Children under 5 Years Old with Down Syndrome and Hypothyroidism

Authors

  • Muhammad Faizi
  • Nur Rochmah
  • Yuni Hisbiyah
  • Anang Endaryanto
  • Soetjipto

DOI:

https://doi.org/10.37506/ijfmt.v16i1.17604

Keywords:

down syndrome, growth, short stature, hypothyroidism

Abstract

Background: Children with Down syndrome tend to have accompanying comorbidities, such as hypothyroidism, and late detection of this ailment leads to reduced growth of the child. This study aimed to assess the growth patterns in children with Down Syndrome and hypothyroidism at diagnosis.
Methods: This cross-sectional study was conducted from September to December 2020 with 56 subjects at the Pediatric Endocrine Outpatient Clinic of Dr. Soetomo Hospital. Diagnosis of Down Syndrome was confirmed by karyotyping, while the weights and heights were assessed using a standardized curve for children with Down Syndrome and then calculated using Peditools. Fifty-six children with Down Syndrome and hypothyroidism were included, comprising 32 boys and 24 girls (mean age, 37.75 ± 34.26 months). Majority of the subjects had normal weight, height, and Body Mass Index (36/56 [mean z-score, −1.62 ± 2.36], 33/56 [mean height-z-score, −0.43 ± 2.74], and 30/56 [mean z-score, −2.00 ± 2.06], respectively). Furthermore, the mean onset of diagnosis was 17.07 ± 32.23 months, where 23 out of the 56 children had short stature and had gotten diagnosed at over 12 months of age.
Conclusion: From the results obtained, hypothyroidism can be said to be associated with reduced growth in children with DS.

Author Biographies

Muhammad Faizi

Doctoral Program of Medical Science, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, Indonesia;  Researcher, Department of Child Health, Dr. Soetomo General Hospital, Faculty of Medicine Universitas Airlangga, Surabaya, East Java, Indonesia

Nur Rochmah

Doctoral Program of Medical Science, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, Indonesia; Researcher, Department of Child Health, Dr. Soetomo General Hospital, Faculty of Medicine Universitas Airlangga, Surabaya, East Java, Indonesia

Yuni Hisbiyah

Doctoral Program of Medical Science, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, Indonesia; Researcher, Department of Child Health, Dr. Soetomo General Hospital, Faculty of Medicine Universitas Airlangga, Surabaya, East Java, Indonesia

Anang Endaryanto

Doctoral Program of Medical Science, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, Indonesia; Researcher, Department of Child Health, Dr. Soetomo General Hospital, Faculty of Medicine Universitas Airlangga, Surabaya, East Java, Indonesia

Soetjipto

Doctoral Program of Medical Science, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, Indonesia; Professor, Department of Medical Biochemistry, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, Indonesia

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Published

2021-11-30

How to Cite

Muhammad Faizi, Nur Rochmah, Yuni Hisbiyah, Anang Endaryanto, & Soetjipto. (2021). Height-for-age in Children under 5 Years Old with Down Syndrome and Hypothyroidism. Indian Journal of Forensic Medicine & Toxicology, 16(1), 831–837. https://doi.org/10.37506/ijfmt.v16i1.17604