Association between Cortisol and Infection Risk of Children with Acute Lymphoblastic Receiving Induction and Consolidation Chemotherapy in Dr. Soetomo General Hospital Surabaya

Authors

  • Tutwuri Handayani
  • Dewa Gede Ugrasena
  • Mia Ratwita Andarsini

DOI:

https://doi.org/10.37506/ijfmt.v16i1.17657

Keywords:

Cortisol, Infection, Chemotherapy, Mortality, ALL children.

Abstract

Background: Mortality due to Infection associated therapy in acute lymphoblastic leukemia (ALL) children remains high, although therapeutic success and survival rate are substantially improving.
Methods: This study used a pre and post-test group design for children aged less than 18 years with ALL newly diagnosed and receiving chemotherapy in pediatric patient of Dr. Soetomo hospital Surabaya.
Results: The study involved 25 subjects, 10 subjects were male, average age ranged from 3 to 9 years. The high risk-ALL subjects were 15 (60%), hyperleukocytosis 4 (16%) subjects and 7 (28%) subjects with leukopenia. Statistical analysis showed a significant difference in decreasing cortisol levels in week-4 compared to week-0 (p <0.001) and an increased in cortisol levels between week-12 compared to week-10. The incidence of infection during induction phase is higher than the consolidation phase (40vs15). The relationship between the mean cortisol levels and the incidence of infection in general showed a significant difference in the induction phase of week-0 (p=0.029), week-4 (p=0.041), and week-6 (p=0.005).
Conclusion: In the induction phase, there is an association between mean cortisol levels and the risk of infection, but there is no such association in the consolidation phase.

Author Biographies

Tutwuri Handayani

Researcher, Pediatric Resident,Faculty of Medicine, Airlangga University, Dr. Soetomo General Hospital, Surabaya, Indonesia

Dewa Gede Ugrasena

Professor, Lecturer, Senior staff in Hematology-Oncology Division, Faculty of Medicine, Airlangga University, Dr. Soetomo General Hospital, Surabaya, Indonesia

Mia Ratwita Andarsini

Lecturer, Senior staff, Head Division of Hematology-Oncology Faculty of Medicine, Airlangga University, Dr. Soetomo General Hospital, Surabaya, Indonesia

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Published

2021-11-30

How to Cite

Tutwuri Handayani, Dewa Gede Ugrasena, & Mia Ratwita Andarsini. (2021). Association between Cortisol and Infection Risk of Children with Acute Lymphoblastic Receiving Induction and Consolidation Chemotherapy in Dr. Soetomo General Hospital Surabaya. Indian Journal of Forensic Medicine & Toxicology, 16(1), 1191–1197. https://doi.org/10.37506/ijfmt.v16i1.17657