Amelogenin Localization in Periodontium Healing of Glucocorticosteriod-Induced Osteoporosis in Rabbit

Authors

  • Nada M. H. Al-Ghaban
  • Nawar Bahjet Kamil
  • BanA.Ghani Jamil
  • Bushra Habeeb Al-Maula

DOI:

https://doi.org/10.37506/ijfmt.v16i1.17705

Keywords:

Periodontium, Amelogenin, Osteoporosis

Abstract

Several recent studies had focused on impact of the changes in osteoporosis and its relation to the
periodontium healing process. The aim of our present study is to evaluate the effect of osteoporosis on
the periodontium healing immunohistochemicaly and on amelogenin. A total of twenty female New
Zealand rabbits were assigned randomly into two groups, a ten healthy (control), and an other ten
were subjected to a glucocorticoid induce osteoporosis. ligatures were haphazardly placed for the 1st
mandibular molars in order to induce periodontitis, then animals had been sacrificed after 4 weeks
and the specimens were processed routinely for a serial decalcified sections for the histological
and the immunohistochemical study on “ amelogenin”. The histological results of our present study
had revealed a delay in the process of healing of periodontium of the experimental group as compared
to the control group. The immunohistochemical findings had shown a higher immunoreactivity of
the periodontium cells of the osteoporotic groups than the control groups. This study found that the
osteoporotic state induced by glucocorticoids may cause a delay in the healing by inducing periodontitis
with a mild to moderate immunoreactivity to amelogenin as compared to the control group.

Author Biographies

Nada M. H. Al-Ghaban

Professor, Department of Oral Diagnosis, College of Dentistry, University of Baghdad,Iraq,

Nawar Bahjet Kamil

Assi.Lecturer, Department of Oral Diagnosis, College of Dentistry, University of Baghdad,Iraq,

BanA.Ghani Jamil

Professor, Department of Oral Diagnosis, College of Dentistry, University of Baghdad,Iraq

Bushra Habeeb Al-Maula

Assistant Professor, Research Center for Laser and Photonics, University of Al-Hamdaniya, Iraq

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Published

2021-11-29

How to Cite

Nada M. H. Al-Ghaban, Nawar Bahjet Kamil, BanA.Ghani Jamil, & Bushra Habeeb Al-Maula. (2021). Amelogenin Localization in Periodontium Healing of Glucocorticosteriod-Induced Osteoporosis in Rabbit. Indian Journal of Forensic Medicine & Toxicology, 16(1), 1451–1457. https://doi.org/10.37506/ijfmt.v16i1.17705