myc Gene and Cancer Variant Analysis and Network Interaction: An In-Silico Analysis

Authors

  • Saeed M Kabrah
  • Talal Qadah
  • Arwa F Flemban

DOI:

https://doi.org/10.37506/ijfmt.v16i1.17791

Keywords:

myc gene, in-silico analysis, gene expression, transcription

Abstract

The myc is a proto-oncogene that regulates the cellular process like cell growth, proliferation,
metabolism, apoptosis and malignancy pathologies. myc deregulation occurs in several cancers and
plays a significant role in disease development, metastatic potential, and therapeutic resistance. Drug
targeting myc in cancer remains highly desirable with substantial challenges, delaying the direct myc
targeted drugs’s development. These drugs target the myc transcriptions deregulations in tumours cell
by compound inhibiting the inducing of epigenetic silencing or regulation of G-quadruplex structures
within the myc promoter. Proteins involved in myc’s post-translational modulation have been identified
as significant surrogate targets for lowering myc activity downstream of aberrant cell stimulatory
signals.

Author Biographies

Saeed M Kabrah

Laboratory Medicine Department, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah,
Kingdom of Saudi Arabia

Talal Qadah

Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences,
King Abdulaziz University, Jeddah, Saudi Arabia,

Arwa F Flemban

 Pathology Department, Faculty of Medicine, Umm Al-Qura University, Makkah, Kingdom of Saudi Arabia

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Published

2021-11-02

How to Cite

Saeed M Kabrah, Talal Qadah, & Arwa F Flemban. (2021). myc Gene and Cancer Variant Analysis and Network Interaction: An In-Silico Analysis. Indian Journal of Forensic Medicine & Toxicology, 16(1), 1594–1608. https://doi.org/10.37506/ijfmt.v16i1.17791