The Association of Low Taurine Levels with Diabetic Neuropathy in Iraqi Patients

Authors

  • Rand Thair Abdulkader
  • Nada A. Kadhim
  • Firas Younus Muhsin

DOI:

https://doi.org/10.37506/ijfmt.v16i1.17806

Keywords:

Type 2 DM, diabetic peripheral neuropathy, taurine, dyslipidemia.

Abstract

Aim of this Study: this study has been carried out to evaluate the role of taurine, and lipid profile in
progression of diabetic complication.
Methods: this work included 81 Iraqi people (age ranged 40-65). Healthy control subjects (G1
group=28), type 2 diabetes mellitus without any complications (G2 group=26), and type 2 diabetes
mellitus with peripheral neuropathy (DPN) (G3 group=27). Diagnosis of the disease was based on
several symptoms and questions under the supervision of the consultant supervisor at the center. Serum
taurine, lipid profile (Cholesterol, triglycerides, HDL, LDL, and VLDL) besides fasting blood glucose
and plasma HbA1c were determined for each participant. Results: The results of taurine revealed that
there was a highly significant decrease in G2 and G3, as compared to G1. The mean values of serum
cholesterol showed no significant difference between G2 and G3 as compared with G1while serum
triglycerides (TG), LDL and VLDL showed a high significant increase in G2 and G3 as compared
to G1. The results of serum HDL levels showed that there was a high significant decrease in G2 and
G3 as compared to G1. No significant differences were found in body mass indices in all the studied
groups while WC, HC, WHR, and WHtR showed high significant increase in G2and G3 as compared
to G1. Systolic blood pressure significantly increased in G2 and G3 while diastolic blood pressure
significantly increased in G3 only.
Conclusion: Serum taurine levels were decreased in patients with T2DM and DPN .The reducing in
taurine synthesis was not related to FBG, HbA1c, and dyslipidemia. We also found that taurine levels
may be more important in the development of diabetes complications.

Author Biographies

Rand Thair Abdulkader

MSc.,  Department of Chemistry, College of Sciences, University of Baghdad, Iraq

Nada A. Kadhim

Prof., Department of Chemistry, College of Sciences, University of Baghdad, Iraq

Firas Younus Muhsin

National Diabetes Center, AlMustansiriya University, Iraq

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Published

2021-11-30

How to Cite

Rand Thair Abdulkader, Nada A. Kadhim, & Firas Younus Muhsin. (2021). The Association of Low Taurine Levels with Diabetic Neuropathy in Iraqi Patients. Indian Journal of Forensic Medicine & Toxicology, 16(1), 1653–1660. https://doi.org/10.37506/ijfmt.v16i1.17806