The Effect of ARV on Rate of HIV Vertical Transmission from Exclusive Breastfeeding Mothers: A Systematic Review


  • Amanah Fatmadani Suwarno
  • Dwiyanti Puspitasari
  • Pudji Lestari



HIV, exclusive breastfeeding, mother-to-child transmission


Objective: To give a visualization and explanation whether the use of ARV during exclusivebreastfeeding
period is able to reduce the rate of transmission during exclusive breastfeeding.
Methods: Systematic review of cross-sectional studies, case control, cohort studies, and prospective
studies using Pubmed, LWW Journals, and Science Direct for literature search. Literature published
between 2010 and 2020 are researched. Results are recorded using PRISMA, MMAT is used for biasrisk
Results: A total of 2090 breastfed infants were included among the 2 studies. The first journal included
was by Coovadiaet al.2012 was a 3rd phase clinical regarding the use of extended NVP on HIV exposed
infants were exclusive breastfed, concluded that the transmission rate for the group that received
extendedNVP was only 1.1%. Rutagweraet al. 2019, focused on the shedding of HIV virus into the
breastmilk which is why this study used breastmilk as their sample4,6. Rutagweraet al. 2019. found
almost 80% of their subjects shed HIV virus into their breastmilk6. This number is correlated to the
transmission of HIV vertically in breastfeeding mother.
Conclusion: To conclude, the use of ARV does affect the rate of transmission of HIV from mother to
child during breastfeeding.

Author Biographies

  • Amanah Fatmadani Suwarno

    Bachelor Student, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

  • Dwiyanti Puspitasari

    Consultant, Department of Paediatrics, Faculty of Medicine, Universitas Airlangga/Dr. Soetomo General Academic Hospital Surabaya, Indonesia,

  • Pudji Lestari

    Senior Lecturer, Department of Public Health Faculty of Medicine,Universitas Airlangga, Surabaya




How to Cite

The Effect of ARV on Rate of HIV Vertical Transmission from Exclusive Breastfeeding Mothers: A Systematic Review. (2022). Indian Journal of Forensic Medicine & Toxicology, 16(2), 56-64.