Serum Levels of Interleukin-2 and Interleukin-6 among Helicobacter Pylori Positive Patients in Relation to Prognosis of Gastro-duodenal Disease

Authors

  • Methaq M. Neamah AL-Hilfi
  • Khairallah A.S Mohammed
  • Naael H. Ali
  • Ali Dawood AL-Hilfi

DOI:

https://doi.org/10.37506/ijfmt.v16i2.17970

Keywords:

: Gastritis; Gastric cancer; Helicobacter pylori; IL-6, IL-2; Peptic ulcer.

Abstract

Background: Helicobacter pylori is the most widespread pathogenic associated with gastro-duodenal
Disease. Interleukin 2 and interleukin 6 are the main cytokines involved in host immune response to
H.pylori infection. The aim of the present study are to assess the serum level of IL-6 and IL–2 in
H.pylori infected patients and to study their association with gastric endoscopy findings. Methods:
One hundred and seven suspected patients and 19 healthy were recruited. The confirmed positivity of
H.pylori detection was based on a rapid urease test (R.U.T) and stool antigen test. Serum concentrations
of IL-2 and IL-6 were measuring by ELISA. Results: Seventy-five (70%) patients were positive for
H.pylori. Both interleukins were found at higher levels in patients than in healthy (p- value <0.05).
Interestingly, the level of IL-2 was lower in patients infected with H.pylori (43.40 pg/ml) than those
who were not infected (85.2 pg/ml), while the level of IL-6 was higher in patients infected with H.pylori
(117 pg/ml) than those not infected (40 pg/ml), p-value <0.05. Furthermore, the increasing levels of
both interleukins were correlated with disease progress.

Author Biographies

  • Methaq M. Neamah AL-Hilfi

    Scholar Researcher, Assist. Prof , College of Health and Medical Technology, Southern Technical University, Basrah, Iraq

  • Khairallah A.S Mohammed

    Assist. Prof., Department of Medical Lab Technology, College of Health and Medical Technology, Southern Technical University, Basrah, Iraq

  • Naael H. Ali

     Scholar Researcher, College of Medicine, University of Basrah, Basrah, Iraq

  • Ali Dawood AL-Hilfi

    Al -Sader Teaching Hospital, Basrah, Iraq

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Published

2022-04-12

How to Cite

Serum Levels of Interleukin-2 and Interleukin-6 among Helicobacter Pylori Positive Patients in Relation to Prognosis of Gastro-duodenal Disease. (2022). Indian Journal of Forensic Medicine & Toxicology, 16(2), 259-265. https://doi.org/10.37506/ijfmt.v16i2.17970