Soluble Antimicrobial Peptide Pyocin of Pseudomonas aeruginosa and its Therapeutics: A Review Article


  • Sura Saleem Alberman
  • EssamFadel Al-wan Al-Jumaili



P. aeruginosa, Bacteriocin, S-type pyocin , Structure, Genetics, therapeutics.


Pyocinsis a bacteriocin produced by a group of Gram-ngative bacteria that belongs to Pseudomonasspecies.
Pyocin is classified as a two distinct families of pyocins. (i) S-type pyocins (colicin-like bacteriocins),
(ii) Tailocins (high-molecular weight bacteriocins that resemble phage tails).The structure of S-type
pyocin is similar to that of colicin except that many S-type pyocins have three domains. Under normal
conditions, the expression of prtN is repressed by PrtR. Upon exposure to stress conditions, such as DNA
damage by chemicals or ultraviolet irradiation, an activated RecA triggers autoproteolytic cleavage of
PrtR, which abrogates prtN repression and leads to pyocinproduction. The outer membrane receptors
for three pyocins have been identified. These are FpvAI, FpvAII and FptA, all of which are involved
in the uptake of iron-siderophore complexes. Before being translocated through the membrane and
killing their target.This is becoming increasingly important as microbial imbalances in the natural gut
flora have been suggested to play a role in a range of chronic diseases such as inflammatory bowel
disease, diabetes, obesity and rheumatoid arthritis.Pyocin has now been shown to have antimicrobial
activity againstbacteria in a biofilm is a limiting factor in the successful treatment of a range of chronic

Author Biographies

  • Sura Saleem Alberman

    Asst. Lec.BologyDept.College of Science.Al-FarabiUniversity Collage Baghdad, Iraq

  • EssamFadel Al-wan Al-Jumaili

    Professor, Biotechnology Dept. Genetic Engineering and Biotechnology Institute for Postgraduate Studies, University of Baghdad.AlJadriya Campus,10071 Baghdad, Iraq




How to Cite

Soluble Antimicrobial Peptide Pyocin of Pseudomonas aeruginosa and its Therapeutics: A Review Article. (2022). Indian Journal of Forensic Medicine & Toxicology, 16(2), 395-403.